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Research • Statistic & Theory
DesigningClinicalResearch, FourthEdition
StephenB.Hulley,MD,MPH
978-1-60831-804-9 • July2013 • Softbound • 7” x10”pp •59Table
Designing Clinical Research
has been extensively revised and
continues to set the standard as a practical guide for doctors, nurses,
pharmacists, and other health professionals involved in all forms of
clinical, translational, and public health research. It presents advanced
epidemiologicconcepts ina reader-friendlyway, and suggestscommon
sense approaches to the challenging judgments involved in designing,
funding, and implementing.
Features
•
NEW!
Approaches to sample sizeestimation, keeping it simple
while coveringmoredesignoptions.
• Examples and ideasonwhat’s new in clinical research.
• Exercises that highlightmajor clinical research issues.
• Treatmentof clinical trial designand implementation.
• Expandedandupdated content inevery chapter,withnewmaterial
on: non-inferiority trials for comparativeeffectiveness research
incidence-density case-control studies confoundingandeffect
modification; diagnostic test studies to informprediction rules;
ethical aspectsofwholegenome sequencing; automateddata
management approaches; newNIHgrant-writing requirements.
• Color format, andElectronic access, poweredby Inkling
™
as a
free companion to the text; viewable throughyour browseror
as adownload to tabletor smartphone ; the complete textwith
optimizednavigation; note-sharing, highlightingandbookmarking
capability; cross-linkingof references and content; rapid search
options linked to thenewglossary.
Table of Contents
Section I:
Basic Ingredients
Ch. 1: Getting Started:TheAnatomy and
Physiology of Clinical Research
Ch. 2: Conceiving theResearchQuestion
andDeveloping the Study Plan
Ch. 3: Choosing the Study Subjects:
Specification, Sampling, andRecruitment
Ch. 4: Planning theMeasurements: Precision,
Accuracy andValidity
Ch. 5: GettingReady toEstimate Sample
Size:Hypotheses andUnderlying Principles
Ch. 6: Estimating Sample Size andPower:
Applications andExamples
Section II:
StudyDesigns
Ch. 7:DesigningCross-Sectional andCohort
Studies
Ch. 8:DesigningCase-Control Studies
Ch. 9: EnhancingCausal Inference in
Observational Studies
Ch. 10:Designing aRandomizedBlinded
Trial
Ch. 11: AlternativeTrialDesigns and
Implementation Issues
Ch. 12:Designing Studies ofMedicalTests
Ch. 13: ResearchUsingExistingData
Section III:
Implementation
Ch. 14: AddressingEthical Issues
Ch. 15:DesigningQuestionnaires, Interviews
andOnline Surveys
Ch. 16;DataManagement
Ch. 17: Implementing the Study andQuality
Control
Ch. 18: Community and International
Studies
Ch. 19:Writing andFunding aResearch
Proposal