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What is an NTCP model?
Complex models have been developed to describe what happens when you
irradiate a patient. These are called
mechanistic
NTCP models.
•
Limited understanding of mechanisms limits the scope of the models
•
Requires too many parameters to allow fitting to clinical data
•
Useful for generating hypotheses and testing methodology
Outcome modelling instead looks for a statistical relationship between
treatment plan parameters and the incidence of a particular complication. This
is called
empirical
or
phenomenological
NTCP modelling.
•
Regression-type models
•
A few parameters fitted to treatment and outcome data
•
Can fill the same purpose as dose-volume constraints
This lecture will focus on empirical NTCP modelling.
05/04/2016