1692-1693 / 2953
Organ architecture
•
Consider normal tissues as consisting of multiple functional subunits (FSU)*,
for tissue repair purposes
•
Each organ different in terms of FSU interaction
•
Parallel type response like a rope: it can perform its function even if some
strands break.
-
Large volume effect
•
Serial type response like a
05/04/2016
Källman et al. Int J Radiat Biol, 1992
chain: function is lost if any
one link breaks.
-
Small volume effect
•
Kidney: nephron
*Withers et al. 1988