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This was all offline ART…

Now: Online Adaptive Re-Planning

M. Ghilezan et al. (2004): Online image-guided intensity-modulated

radiotherapy for prostate cancer: How much improvement can we expect? A

theoretical assessment of clinical benefits and potential dose escalation by

improving precision and accuracy of radiation therapy. IJRPBP 60(5)

Idealized assumptions to investigate a ‘gold-standard’ benchmark online ART

scheme:

daily pre-treatment imaging and online IMRT replanning

no intrafractional or other uncertainties => no PTV-margin necessary

ESTRO IMRT course 2016

Adaptive Radiotherapy

London April 7th, 2016

-32-

IMRT

plan

CT

Fx

1

no margin!

IMRT

plan

CT

Fx

2

IMRT

plan

CT

Fx

N

evaluation using deformable dose accumulation of multiple CTs of 18 patients