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27

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

S

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Y

F

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271-P

os

B

oard

B51

THERMODYNAMIC PROPERTIES OF ELP-LABELLED

DOXORUBICIN, A DRUG DELIVERY SYSTEM.

Valeria Zai-Rose

272-P

os

B

oard

B52

UNDERSTANDING THE FUNCTION OF A PRO-ANGIOGENIC

POLYPEPTIDE HFGF-1 WITH A CANCER INHIBITOR

IMATINIB.

Tulsi Modi

, Oluwadamilola Filani, Jason Payne, Raja

Murthy

273-P

os

B

oard

B53

A SHARED BINDING SITE FOR PROPOFOL AND THIOPENTAL

IN ELIC.

Monica N. Kinde

, Weiming Bu, Edom Seyoum, Qiang Chen,

Marta M. Wells, David D. Mowrey, Roderic G. Eckenhoff, Yan Xu, Pei

Tang

274-P

os

B

oard

B54

CRYSTAL VIEW OF ANESTHETICS AND ALCOHOLS BOUND IN

THE PORE OF ELIC.

Qiang Chen

, Monica N. Kinde, Aina E. Cohen,

Pei Tang, Yan Xu

275-P

os

B

oard

B55

ANALYSIS OF ANTIFOLATE DRUGS WITH DISEASE TISSUE

SPECIFICITY.

Siobhan M. Deis

, Charles E. Dann III

276-P

os

B

oard

B56

PKA-DEPENDENT POTENTIATION MECHANISMS OF HUMAN

CFTR ACTIVITY.

Guangyu Wang

277-P

os

B

oard

B57

KINASE STRUCTURAL DYNAMICS ENABLES TIGHT AND

SELECTIVE BINDING OF INHIBITORS.

Roman V. Agafonov

, Chris

Wilson, Vanessa Buosi, Renee Otten, Dorothee Kern

278-P

os

B

oard

B58

education

travel awardee

cpow mid

-

career

travel awardee

GLUTATHIONE REDUCTASE OF

PLASMODIUM FALCIPARUM

AS AN ANTIMALARIAL DRUG TARGET OF METHYLENE

BLUE.

Socheata Lim

, Judith H. Prieto

279-P

os

B

oard

B59

EFFECTS OF MOLECULAR CROWDING ON THE BINDING

AFFINITY OF DIHYDROFOLATE FOR DIHYDROFOLATE

REDUCTASE.

Michael R. Duff

, Elizabeth E. Howell

280-P

os

B

oard

B60

QUANTIFYING THE INFLUENCE OF THE CROWDED

CYTOPLASM ON SMALL BIOMOLECULE DIFFUSION VIA

HOMOGENIZATION THEORY.

Peter M. Kekenes-Huskey

, Caitlin

E. Scott

281-P

os

B

oard

B61

SPECIFIC OR GENERAL - IT IS ALL ABOUT SOLUTE

INTERACTIONS WITH THE PORE.

Ekaterina M. Nestorovich

,

Sergey M. Bezrukov

282-P

os

B

oard

B62

USING SEDIMENTATION VELOCITY TO INVESTIGATE THE

NUCLEOTIDE-LINKED ASSEMBLY OF E. COLI CLPA.

Ryan P. Stafford

, Aaron L. Lucius

283-P

os

B

oard

B63

MACROMOLECULAR CROWDER AND LIGAND COMPETE

FOR THE CLOSED DOMAIN CLEFT OF MALTOSE BINDING

PROTEIN.

Archishman Ghosh

, Huan-Xiang Zhou

284-P

os

B

oard

B64

CHARACTERIZATION OF THE CALCIUM-BINDING AND

PEPTIDE-BINDING PROPERTIES OF ARRHYTHMOGENIC

CALMODULIN MUTANTS.

Shane D. Walton

, Norma M. Elizaga,

Hsiang-Ting Ho, Jalal K. Siddiqui, Andrew J. O’Neil, Bin Liu, Sandor

Gyorke, Jonathan P. Davis

285-P

os

B

oard

B65

LIPOYLATION MECHANISM OF P. FALCIPARUM

MITOCHONDRIAL PROTEINS.

Alfredo J. Guerra

, Gustavo A.

Afandor, Russell P. Swift, Sean T. Prigge

286-P

os

B

oard

B66

UNDERSTANDING THE MOLECULAR DETERMINANTS OF

CAPSAICIN MODE OF ACTION.

Khaled M. Elokely

, Eugene

Palovack, Lucie Delemotte, Vincenzo Carnevale, Michael L. Klein

Protein Dynamics and Allostery I

(Boards B67-B88)

287-P

os

B

oard

B67

FORMATION AND DEGRADATION OF INTERMEDIATE

HEMOGLOBIN POLYMERS ARE RESPONSIBLE FOR THE

COOPERATIVITY OF OXYGEN BINDING ISOTHERMS.

Enrico Bucci

, Stefania Pucciarelli, Mauro Angeletti

288-P

os

B

oard

B68

ROLE OF IONIC STRENGTH AND THE BOHR EFFECT IN

MODULATING THERMODYNAMIC PROFILES ASSOCIATED

WITH CO ESCAPE IN RICE NON-SYMBIOTIC HEMOGLOBIN

1.

David Butcher

, Jaroslava Miksovska

289-P

os

B

oard

B69

THE “CAGED” STATE, THE TRANSITION STATE

OF THE REGULATION OF OXYGEN-AFFINITY IN

HEMOGLOBIN.

Takashi Yonetani

, Kenji Kanaori

290-P

os

B

oard

B70

UNDERSTANDING THERMODYNAMICS OF

CONFORMATIONAL CHANGE IN THE F-ATPASE.

Nicholas Leioatts

, Helmut Grubmüller

291-P

os

B

oard

B71

KINETIC CONTROL OF O2 REACTIVITY IN H-NOX

DOMAINS.

Abdelkrim Benabbas

, Yuhan Sun, Weiqiao Zeng, Sandhya

Muralidharan, Elizabeth Boon, Paul Champion

292-P

os

B

oard

B72

PROBING FLEETING INTERACTIONS IN LARGE AND

DYNAMIC NONRIBOSOMAL PEPTIDE SYNTHETASES WITH

NOVEL NMR METHODS.

Dominique P. Frueh

, Andrew C.

Goodrich, Bradley J. Harden, Scott R. Nichols, Subrata H. Mishra

293-P

os

B

oard

B73

education

travel awardee

VISUALIZING THE INTER-DOMAIN MOTIONS OF A

PATHOGENIC PROTEIN USING SPARSE RDC DATA.

Yang Qi

,

Jeffrey W. Martin, Anthony Yan, Francois Thelot, Bruce R. Donald,

Terrence G. Oas

294-P

os

B

oard

B74

MAPPING THE CONFORMATIONAL DYNAMICS OF THE

SCAFFOLD PROTEIN PSD-95.

Claus A.M. Seidel

, Jakub Kubiak,

Suren Felekyan, Daniel Rohrbeck, James J. McCann, Mark E. Bowen