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26

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

247-P

os

B

oard

B27

CPSF30, A NOVEL NON-CLASSICAL ZINC FINGER PROTEIN

THAT UTILIZES IRON & ZINC COORDINATION FOR RNA

RECOGNITION.

Geoffrey Shimberg

, Jamie Michalek, Andria

Rodrigues, Timothy Stemmler, Sarah Michel

Protein Folding and Chaperones

(Boards B28-B45)

248-P

os

B

oard

B28

TRANSITION PATH TIMES IN PROTEIN FOLDING STUDIED

BY STRUCTURE-BASED SIMULATION.

Mashiho Ito

, Shoji Takada

249-P

os

B

oard

B29

FOLDING RATES FROM THERMODYNAMICS SIMULATIONS:

APOAZURIN AS AN EXAMPLE.

Dirar M. Homouz

, Margaret S.

Cheung

250-P

os

B

oard

B30

BARRIERLESS TRANSITION IDENTIFIED DURING FOLDING

OF BARSTAR BY USING TIME-RESOLVED FRET FROM

5-FLUROTRYPTOPHAN.

Guruswamy Krishnamoorthy

, Anju Yadav,

Jayant Udgaonkar

251-P

os

B

oard

B31

DEVELOPMENT OF THE LINE CONFOCAL SYSTEM FOR

THE SINGLE MOLECULE TRACKING OF FAST FOLDING

DYNAMICS OF PROTEINS.

Hiroyuki Oikawa

, Kiyoto Kamagata,

Munehito Arai, Atsuhito Fukasawa, Hiroaki Yokota, Toru Ide, Satoshi

Takahashi

252-P

os

B

oard

B32

COILED COIL PROBES CAPTURE THE MECHANICAL

UNFOLDING PATHWAY OF A LARGE PROTEIN.

Qing Li

, Zackary

N. Scholl, Piotr E. Marszalek

253-P

os

B

oard

B33

FAST CLOSURE OF LONG LOOPS AT THE INITIATION OF

FOLDING OF GLOBULAR PROTEINS STUDIED BY FRET

BASED METHODS.

Elisha Haas

254-P

os

B

oard

B34

BASIC RESIDUE AT POSITION 14 IS NOT REQUIRED FOR

FAST ASSEMBLY AND DISASSEMBLY KINETICS IN NEURAL

CADHERIN.

Nagamani Vunnam

, Nathan I. Hammer, Susan Pedigo

255-P

os

B

oard

B35

EFFECTS OF CROWDING AGENTS AND VOLUME EXCLUSION

ON AMYLOID BETA FIBRILLATION.

Joe Hakim

, Santiago Schnell

256-P

os

B

oard

B36

ENTHALPY MEDIATED PROTEIN STABILIZATION BY

MACROMOLECULAR CROWDING.

Michael Senske

, Lisa Törk,

Benjamin Born, Martina Havenith, Christian Herrmann, Simon

Ebbinghaus

257-P

os

B

oard

B37

CROWDING AND THE ORIGIN OF ENTHALPIC DEPLETION

FORCES IN PROTEIN INTERACTIONS.

Daniel Harries

, Liel Sapir

258-P

os

B

oard

B38

PROTEIN-PROTEIN INTERACTIONS AFFECT NATIVE STATE

STABILITY IN CROWDED ENVIRONMENTS.

Alan E. van Giessen

,

Bryanne Macdonald, Shannon McCarley, Sundus Noeen, Rabeb Layouni

259-P

os

B

oard

B39

THERMALLY INDUCED STRUCTURAL CHANGES IN

AN ARMADILLO REPEAT PROTEIN SUGGEST A NOVEL

THERMOSENSOR MECHANISM IN A MOLECULAR

CHAPERONE. Paul Nicholls, Paul Bujalowski, Jose Barral,

Andres Oberhauser

260-P

os

B

oard

B40

CCT5: A MODEL PROTEIN FOLDING MACHINE.

Kelly M. Knee

,

Dipali Patel, Oksana Sergeeva, John J. Kelly, Jay M. Janz, Jonathan A.

King, Wyatt Yue, Christine Bulawa

261-P

os

B

oard

B41

HOW DO GROUP II CHAPERONINS DISTINGUISH THEIR

PARTIALLY FOLDED SUBSTRATES FROM THE NATIVE

STATES?

Jonathan A. King

, Oksana Sergeeva, Kelly M. Knee

262-P

os

B

oard

B42

REAL TIME NMR FOLDING STUDY OF THE HUMAN GAMMA

D CRYSTALLIN IN THE PRESENCE OF METAL IONS.

Lina Rivillas-Acevedo

, Liliana Quintanar, Jonathan King, Carlos Amero

263-P

os

B

oard

B43

MODULATION OF THE

α

−CRYSTALLIN CHAPERON ACTIVITY

INDUCED BY CHANGES IN THE EXPOSED SURFACE.

Marco De Spirito

, Michela Chiarpotto, Gabriele Ciasca, Giuseppe

Maulucci, Valentina Palmieri, Massimiliano Papi

264-P

os

B

oard

B44

CHAPERONES RESCUE LUCIFERASE FOLDING BY

SEPARATING ITS DOMAINS.

Zackary N. Scholl

, Weitao Yang, Piotr

Marszalek

265-P

os

B

oard

B45

education

travel awardee

INTER-DOMAIN DYNAMICS OF A NOVEL CHAPERONE

ENABLES EFFECTIVE CAPTURE OF MEMBRANE PROTEIN

SUBSTRATES.

Fu-Cheng Liang

, Camille McAvoy, Samantha

Piszkiewicz, Gerard J. Kroon, Maria Yamout, Peter Wright, Shu-ou Shan

Protein-Small Molecule Interactions I

(Boards B46-B66)

266-P

os

B

oard

B46

DETERMINATION OF BIOMOLECULAR INTERACTIONS

USING MICROSCALE THERMOPHORESIS.

Nicole Bouley Ford

267-P

os

B

oard

B47

RATIONAL DESIGN OF SURFACE MODIFIED

NANOPARTICLES FOR MODULATION OF AMYLOID BETA

AGGREGATION.

Nicholas P. van der Munnik

268-P

os

B

oard

B48

PROBING THE DEPENDENCE OF PH ON SUGAR BINDING

AND PROTEIN STRUCTURE IN A POLYSACCHARIDE

LYASE. Sook Wong,

Jeffery B. Klauda

269-P

os

B

oard

B49

PROBING THE ROLE OF CONFORMATIONAL ENTROPY IN

PROTEIN-INHIBITOR BINDING.

Kyle Harpole

, Senthil Kumar

Ganesan, Wolfgang Peti, A. Joshua Wand

270-P

os

B

oard

B50

LIGAND DISCOVERY FOR THE ALANINE-SERINE-CYSTEINE

TRANSPORTER (ASCT2, SLC1A5) FROM HOMOLOGY

MODELING AND VIRTUAL SCREENING.

Claire Colas

, Christoph

Grewer, Armanda Gameiro, Thomas Albers, Kurnvir Singh, Nicholas J.

Otte, Helen Shere, Bonomi Massimiliano, Jeff Holst, Avner Schlessinger