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25

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

S

A

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D

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Y

F

R

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D

A

Y

Protein Structure and Conformation I

(Boards B1-B27)

221-P

os

B

oard

B1

CHASING UNFOLDING INTERMEDIATES OF IG LIGHT

CHAINS WITH RESIDUAL STRUCTURES THAT COULD FIT IN

AN AMYLOID CORE.

Gilberto Valdes-Garcia

, Cesar Millan-Pacheco,

Nina Pastor

222-P

os

B

oard

B2

international

travel awardee

BACKBONE DYNAMICS MODULATES THE AMYLOIDOGENIC

PROPENSITY OF TRANSTHYRETIN THROUGH NON-NATIVE

INTERMEDIATES.

Aritra Bej

, Jitendra K. Das, Shyam S. Mall, Sujoy

Mukherjee

223-P

os

B

oard

B3

SELF-REPLICATION OF TRANSTHYRETIN AMYLOID

AGGREGATES FROM NATIVE TETRAMERS IN VITRO.

Mentor Mulaj

, Tatiana Miti, Martin Muschol

224-P

os

B

oard

B4

SAS PROFILE CORRELATIONS REVEAL THE HIERARCHICAL

NATURE OF SAS DATA AND SUGGEST NEW SCORING

STRATEGIES.

Michael Nilges

, Yannick G. Spill

225-P

os

B

oard

B5

COMPUTATIONAL MODELING OF BETA-FIBRILS.

Hamed Tabatabaei Ghomi

, Elizabeth M. Topp, Markus M. Lill

226-P

os

B

oard

B6

THE RESVERATROL DERIVATIVE PICEATANNOL ALTERS THE

CONFORMATION OF ALZHEIMER’S DISEASE ASSOCIATED A

β

PROTEIN AGGREGATES.

Yiying Wang

, Melissa A. Moss

227-P

os

B

oard

B7

EFFECT OF HYDROPHOBIC RESIDUES ON INTERFACIAL

FIBRILLIZATION KINETICS.

Samantha McBride

, Chris Tilger, Amir

Hirsa

228-P

os

B

oard

B8

AGGREGATION PROPENSITY OF PRION IS KINETICALLY

CONTROLLED BY INTRAMOLECULAR DIFFUSION OF

PROTEIN CHAIN.

Kinshuk R. Srivastava

, Lisa J. Lapidus

229-P

os

B

oard

B9

PROBING TEMPERATURE DEPENDENT CONFORMATION

CHANGE OF CALMODULIN PROTEIN USING MOLECULAR

DYNAMICS SIMULATIONS.

Sunita Negi

230-P

os

B

oard

B10

UNDERSTANDING FORCE-FIELD BIAS IN PIN1WW.

Alexandra Iuga

231-P

os

B

oard

B11

“PUSH AND PULL” HYPOTHESIS TO UNIFY THE PHYSICAL

AND CHEMICAL UNFOLDING OF PROTEINS.

Guilherme A. de Oliveira

, Jerson L. Silva

232-P

os

B

oard

B12

PROBE THE HEME IRON LIGAND AND CONFORMATIONAL

CHANGE OF MISFOLDED STATES OF CYTOCHROME C

THROUGH EPR SPECTROSCOPY.

Qing Huang

, Zhigang Ke,

Guohua Yao, Shanshan Ma, Jonathan Soffer

233-P

os

B

oard

B13

CONSTANT PH SIMULATIONS WITH THE DOUBLE

RESERVOIR PH REPLICA EXCHANGE.

Ana Damjanovic

, Benjamin

T. Miller, Asim Okur, Bertrand Garcia-Moreno, Bernard R. Brooks

234-P

os

B

oard

B14

DETERMINANTS OF DOMAIN SWAPPING IN

STAPHYLOCOCCAL NUCLEASE.

Meredith Peck

, Ilaria Caturegli,

Jamie L. Schlessman, Aaron Robinson, Bertrand Garcia-Moreno E.

235-P

os

B

oard

B15

MOLECULAR BASIS OF TETRAMERIZATION AND PH-

GATING IN THE KCSA POTASSIUM CHANNEL CYTOPLASMIC

DOMAIN. Guy Kamnesky, Orel Hirschhorn, Hadassa Shaked, Jingfei

Chen, Lishan Yao,

Jordan H. Chill

236-P

os

B

oard

B16

CHARACTERIZING A NEW METAL BINDING SITE IN

S100B.

Zephan Melville

, Kristen Varney, Michael Cavalier, Sean Stowe,

Dylan Weber, Eric Toth, David Weber

237-P

os

B

oard

B17

NMR CHARACTERIZATION OF AN UNUSUAL 37

KDA EPIMERIZATION DOMAIN OF YERSINABACTIN

SYNTHETASE.

Scott R. Nichols

, Dominique P. Frueh

238-P

os

B

oard

B18

FIBRINOGEN HYDRODYNAMIC PROPERTIES FROM NMR-

DIFFUSION STUDIES.

Rustem I. Litvinov

, Bulat Z. Idiyatullin,

Dilyafruz R. Bakirova, Dzhigangir A. Faizullin, Rauf H. Kurbanov, John

W. Weisel, Yuriy F. Zuev

239-P

os

B

oard

B19

SITE-RESOLVED MEASUREMENTS OF PROTEIN HYDRATION

DYNAMICS.

Bryan S. Marques

, Christine Jorge, Nathaniel V. Nucci,

Bertrand E. Garcia-Moreno, A. Joshua Wand

240-P

os

B

oard

B20

INTERNAL CAVITIES AND THEIR ROLE AS DETERMINANTS

OF PRESSURE UNFOLDING OF PROTEINS.

Jose A. Caro

, Mariano

Dellarole, Martin Fossat, Jamie L. Schlessman, Christian Roumestand,

Catherine A. Royer, Bertrand Garcia-Moreno E

241-P

os

B

oard

B21

CRYSTAL STRUCTURES OF STREPTOCOCCUS PYOGENES

CAS2 PROTEIN AT VARIOUS PH CONDITIONS.

Ugeene Jeong

242-P

os

B

oard

B22

CRYSTAL STRUCTURES OF STREPTOCOCCUS PYOGENES AND

XANTHOMONAS ORYZAE CAS5D PROTEINS.

Donghyun Ka

,

Euiyoung Bae

243-P

os

B

oard

B23

UNDERSTANDING STRUCTURAL AND DYNAMIC EFFECTS

INDUCED BY KEY COMPONENTS OF THE HCV POLYMERASE

REPLICATION COMPLEX.

Ester Sesmero

, Ian F. Thorpe

244-P

os

B

oard

B24

MODELING MACROMOLECULAR BODIES USING 3D MEDIAL

AXIS TRANSFORMS AND NORMAL MODE ANALYSIS. Lance

Edens, Adam Goler, Suhyun Yoon, James A. Brozik,

David J. Keller

245-P

os

B

oard

B25

SIMULATING PROTEIN AND NUCLEIC ACID DYNAMICS ON

THE MICROSECOND TO MILLISECOND TIMESCALE.

Hai Nguyen

, James Maier, He Huang, Victoria Perrone, Alberto Perez,

Carlos Simmerling

246-P

os

B

oard

B26

education

travel awardee

ENVIRONMENTAL AND MUTATION EFFECTS ON THE

FOLDING AND DNA-BINDING OF THE PRIMARY DNA

RECOGNITION SUBDOMAIN OF SLEEPING BEAUTY

TRANSPOSASE.

Gage Leighton

, Tatiana Konnova, Irina Nesmelova