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28

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

295-P

os

B

oard

B75

cpow mid

-

career

travel awardee

PROBING THE DOMAIN MOTIONS OF AN OLIGOMERIC

PROTEIN FROM DEEP-SEA HYPERTHERMOPHILE BY

NEUTRON SPIN ECHO. Debsindhu Bhowmik, Gurpreet Kaur

Dhindsa, Andrew J. Rusek, Kurt Van Delinder, Utsab Shrestha, Joseph D.

Ng, Melissa Sharp, Laura R. Stingaciu,

Xiang-qiang Chu

296-P

os

B

oard

B76

THE MECHANISM OF POPULATION SHIFTING AMONG

TRANSITION STATES OF ADENYLATE KINASE.

Yujing Wang

,

Emre Onuk, Lee Makowski

297-P

os

B

oard

B77

cpow

travel awardee

MOLECULAR MECHANISM OF RUTHENIUM AND GOLD

ANTICANCER AGENTS IN THE ALLOSTERIC REGULATION OF

THE HISTONE PROTEINS OF CHROMATIN.

Giulia Palermo

, Tina

Riedel, Curt Alexander Davey, Paul Joseph Dyson, Ursula Rothlisberger

298-P

os

B

oard

B78

CHARACTERIZING NUCLEOTIDE DEPENDENT ALLOSTERY

IN G-PROTEINS WITH MOLECULAR DYNAMICS AND

NORMAL MODE ANALYSIS.

Xin-Qiu Yao

, Lars Skjærven, Barry J.

Grant

299-P

os

B

oard

B79

THE EFFECT OF CRYSTAL CONTACT FORCES ON PROTEIN

INTRAMOLECULAR DYNAMICS.

Andrea Markelz

, Katherine

Niessen, Mengyang Xu

300-P

os

B

oard

B80

THERMODYNAMIC AND DYNAMIC BASIS FOR THE

BROADENED LIGAND SPECIFICITY OF A TIAM2 PDZ DOMAIN

MUTANT.

Ernesto J. Fuentes

, Xu Liu, Lisa C. Golden, Liping Yu

301-P

os

B

oard

B81

RELATIVE MECHANICAL FLEXIBILITY OF UBIQUITIN

FAMILY PROTEINS: A STUDY USING ELASTIC NETWORK

MODEL.

Ranja Sarkar

, Hemachandra Kotamarthi, A.S.R Koti, Ravi

Venkatramani

302-P

os

B

oard

B82

MOTION AND CONFORMATIONAL ENTROPY IN PROTEIN

FUNCTION: CREATION OF AN NMR-BASED ENTROPY

METER. Vignesh Kasinath, Kyle W. Harpole, Veronica R. Moorman,

Kathleen G. Valentine, Kendra K. Frederick, Kim A. Sharp,

Joshua Wand

303-P

os

B

oard

B83

A TOOL SET TO MAP DYNAMIC ALLOSTERIC NETWORKS

THROUGH THE NMR CHEMICAL SHIFT COVARIANCE

ANALYSIS (CHESCA). Stephen Boulton, Madoka Akimoto, Rajeevan

Selvaratnam, Amir Bashiri,

Giuseppe Melacini

304-P

os

B

oard

B84

education

travel awardee

PROBING MULTIPLE TIMESCALE DYNAMICS OF PROTEIN

KINASE A-INHIBITOR COMPLEXES.

Geoffrey Li

, Jonggul Kim,

Frank Chao, Leanna McDonald, Gianluigi Veglia

305-P

os

B

oard

B85

LONG-RANGE PROTEIN VIBRATIONS DEPENDENCE ON

LIGAND BINDING: RATE PROMOTING MOTIONS.

Katherine A. Niessen

, Edward Snell, Andrea G. Markelz

306-P

os

B

oard

B86

RHODOPSIN PHOTOACTIVATION DYNAMICS REVEALED BY

QUASI-ELASTIC NEUTRON SCATTERING.

Debsindhu Bhowmik

,

Utsab Shrestha, Suchithranga M. d. c. Perera, Udeep Chawla, Eugene

Mamontov, Michael F. Brown, Xiang-Qiang Chu

307-P

os

B

oard

B87

ROLE OF STRUCTURAL FLEXIBILITY OF CPSRP43 IN

BINDING SUBSTRATES DURING POST-TRANSLATIONAL

TARGETING. Feng Gao, Alicia D. Kight, Rory C. Henderson, Srinivas

Jayanthi, Parth Patel, Robyn L. Goforth, T.K.S. Kumar, Ralph L. Henry,

Colin D. Heyes

308-P

os

B

oard

B88

FLUCTUATIONS WITHIN THE HYDROGEN BOND

NETWORK MODULATE COOPERATIVITY ACROSS

THE CONFORMATIONAL ENSEMBLE OF PROTEIN

STRUCTURES.

Brittany K. Smith

, Donald J. Jacobs, Dennis R. Livesay

Intrinsically Disordered Proteins (IDP) and

Aggregates I (Boards B89-B115)

309-P

os

B

oard

B89

ANOMALOUS STIFFNESS CHANGES OF TAU PROTEIN IN

X-RAY SINGLE MOLECULE OBSERVATIONS.

Masahiro Shimura

,

Yuufuku Matsushita, Keigo Ikezaki, Kouhei Ichiyanagi, Tomohiro

Miyasaka, Sekiguchi Hiroshi, Yasuo Ihara, Yuji C. Sasaki

310-P

os

B

oard

B90

SIMULATION OF THE DISTRIBUTION OF DISORDERED TAU

PROTEINS AROUND ITS AMYLOID FIBRILS CORE. Liang Xu,

Martin Margittai, Ruth Nussinov,

Buyong Ma

311-P

os

B

oard

B91

minority affairs

travel awardee

TAU FILAMENT LENGTH DISTRIBUTION REFLECTS END-TO-

END ANNEALING.

Carol J. Huseby

, Ralf Bundschuh, Jeff Kuret

312-P

os

B

oard

B92

PARAMETER DISTRIBUTION ANALYSIS OF TAU FRAGMENT

K18 FIBRILLIZATION.

Eri Nakatani-Webster

, Shaylin L. Higgins,

Abhinav Nath

313-P

os

B

oard

B93

HOW UNFOLDED IS TAU?

Arash Foroutan

, Anne Skaja Robinson

314-P

os

B

oard

B94

DISEASE RELATED POINT

MUTATIONS AND SOLUTION CONDITIONS DETERMINE

FIBRILLIZATION BEHAVIOR OF

α

-SYNUCLEIN.

Arshdeep Sidhu

, Ine Segers Nolten, Vinod

Subramaniam

315-P

os

B

oard

B95

FIBRIL BREAKING ACCELERATES

α

-SYNUCLEIN

FIBRILLIZATION.

Volodymyr V. Shvadchak

, Mireille M.A.E.

Claessens, Vinod Subramaniam

316-P

os

B

oard

B96

EXPLORING THE PHASE SPACE OF

Α

LPHA-SYNUCLEIN WITH

REPLICA EXCHANGE SIMULATIONS.

Marcin A. Nowosielski

, Peter

G. Bolhuis

317-P

os

B

oard

B97

SINGLE MOLECULE FLUORESCENCE ASSAY OF ALPHA

SYNUCLEIN DIMERIZATION.

Zhengjian Lv

, Alexey V.

Krasnoslobodtsev, Yuliang Zhang, Daniel Ysselstein, Jean-Christophe

Rochet, Scott Blanchard, Yuri L. Lyubchenko

318-P

os

B

oard

B98

ALPHA SYNUCLEIN’S ANOMALOUS STRUCTURAL

FLUCTUATIONS IN X-RAY SINGLE MOLECULE

OBSERVATIONS.

Naruki Hara

, Masahiro Shimura, Yufuku Matsushita,

Keigo Ikezaki, Hiroshi Sekiguchi, Yasushi Kawata, Yuji C. Sasaki