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35

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

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470-P

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B

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B250

BIOINFORMATIC METHODS FOR THE RAPID

IDENTIFICATION OF THERMOSTABILIZING MUTANTS.

David B. Sauer

, Nathan K. Karpowich, Da-Neng Wang

471-P

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B251

INTERACTION OF THE PHAGE ENDOLYSIN PLYC WITH

MODEL MEMBRANES.

Marilia Barros

, Tarek Vennemann, Frank

Heinrich, Daniel Nelson, Mathias Lösche

472-P

os

B

oard

B252

education

travel awardee

STRUCTURAL BASIS OF PHOSPHOINOSITIDE (PIP)

RECOGNITION BY THE TIRAP PIP-BINDING MOTIF.

Xiaolin Zhao

, Shuyan Xiao, Sam Berk, Anne M. Brown, David R. Bevan,

Geoffrey Armstrong, Daniel G.S. Capelluto

473-P

os

B

oard

B253

MECHANISM OF ACTION OF SALT ADAPTATION MUTATIONS

IN ARTEMIA FRANCISCANA.

Jessica Eastman

, Sukanyalakshmi

Chebrolu, Pablo Artigas

474-P

os

B

oard

B254

DETERMINING OLIGOMERIC ORDER OF A MEMBRANE

PROTEIN BY DOUBLE ELECTRON-ELECTRON RESONANCE

SPECTROSCOPY. Sergey Milikisiyants, Shenlin Wang, Rachel Munro,

Matthew Donohue, Leonid S. Brown, Tatyana I. Smirnova, Vladimir

Ladizhansky,

Alex I. Smirnov

475-P

os

B

oard

B255

NUCLEOTIDE-DEPENDENT MEMBRANE INTERACTION

AND DIMERIZATION OF K-RAS4B.

Hyunbum Jang

, Shaoyong

Lu, Mayukh Chakrabarti, Lyuba Khavrutskii, Nadya I. Tarasova, Vadim

Gaponenko, Ruth Nussinov

476-P

os

B

oard

B256

education

travel awardee

FORMING THE PSEUDOMONAS AERUGINOSA TRANSLOCON

REQUIRES SIMULTANEOUS INCORPORATION OF POPB AND

POPD.

Kathryn R. Monopoli

, Alejandro P. Heuck

477-P

os

B

oard

B257

INVESTIGATING THE FUNCTIONAL ROLE OF THE

TRANSMEMBRANE SEGMENTS OF YTA10, A SUBUNIT

OF THE MAAA PROTEASE, IN MEMBRANE PROTEIN

DEGRADATION.

Hunsang Lee

, Hyun Kim

478-P

os

B

oard

B258

OLIGOMER STOICHIOMETRY OF MEMBRANE-BOUND

PROTEINS INVOLVED IN A COOPERATIVE PARTITION

EQUILIBRIUM: A HOMO-FRET STUDY. Ana M. Melo, A. Fedorov,

M. Prieto,

Ana Coutinho

Membrane Receptors and Signal

Transduction I (Boards B259-B280)

479-P

os

B

oard

B259

ACTIVATION AND DRUG DESIGN OF A MUSCARINIC

G-PROTEIN COUPLED RECEPTOR.

Yinglong Miao

, J. Andrew

McCammon

480-P

os

B

oard

B260

ALLOSTERIC EFFECTS OF G-PROTEIN COUPLED RECEPTOR

HETEROMERIZATION: RELEVANCE TO PSYCHOSIS.

Jason Younkin

, Lia Baki, Amr Ellaithy, Diomedes E. Logothetis

481-P

os

B

oard

B261

MICROTUBULES SHAPE GPCR SPATIOTEMPORAL MEMBRANE

ORGANIZATION AND FUNCTION BY SCAFFOLDING

CORTICAL SIGNALING HUBS. Sandra de Keijzer, Marjolein B.M.

Meddens, Samantha L. Schwartz, Peter J. Bosch, Ben Joosten, Johannes S.

Kanger, Vinod Subramaniam, Diane S. Lidke,

Alessandra Cambi

482-P

os

B

oard

B262

LOCALIZATION AND DYNAMICS OF BETA-ADRENERGIC

RECEPTOR MEDIATED EGFR TRANSACTIVATION ON MICRO-

PATTERNED SURFACES.

Peter Lanzerstorfer

, Ulrike Müller, Diana

Zindel, Otmar Höglinger, Cornelius Krasel, Moritz Bünemann, Julian

Weghuber

483-P

os

B

oard

B263

MEMBRANE CURVATURE REGULATES THE LOCALIZATION

OF G PROTEIN COUPLED RECEPTORS AND RAS

ISOFORMS.

Dimitrios Stamou

, Kadla Rosholm, Alexander Damalas,

Nikos Hatzakis, Volker Wirth, Karen Martinez, Natascha Leijnse, Lene

Oddershede, Poul Martin Bendix, Soren Pedersen

484-P

os

B

oard

B264

MOLECULAR SIGNATURES OF G-PROTEIN COUPLED

RECEPTORS IN PANCREATIC CANCER USING SUPER-

RESOLUTION MICROSCOPY. Raphael Jorand, Ottavia Golfetto,

Sunetra Biswas, Steven J. Tobin, Huiying Zhang, Vladana Vukojevic,

Tijana Jovanovic-Talisman

485-P

os

B

oard

B265

REAL TIME OBSERVATION OF LIGAND BINDING TO A GPCR:

CONFORMATIONAL SELECTION GOVERNS THE ABILITY

OF RETINALS TO BIND OPSIN.

Christopher T. Schafer

, David L.

Farrens

486-P

os

B

oard

B266

NOVEL CHEMICAL BIOLOGY METHODS ILLUMINATE

THE FUNCTION OF SINGLE G PROTEIN-COUPLED

RECEPTORS.

Thomas Huber

, Thomas P. Sakmar

487-P

os

B

oard

B267

POLYMER-BASED NANODISCS FOR STUDYING STRUCTURE

AND DYNAMICS OF G-PROTEIN-COUPLED RECEPTORS.

Jana Broecker

, Takefumi Morizumi, Wei-Lin Ou, Oliver P. Ernst

488-P

os

B

oard

B268

TRACKING VOLTAGE-SENSITIVE MOVEMENTS OF THE M2

MUSCARINIC ACETYLCHOLINE RECEPTOR.

Michael F. Priest

,

Noa Dekel, Ofra Barchad-Avitzur, Yair Ben-Chaim, Francisco Bezanilla

489-P

os

B

oard

B269

BETA-ARRESTIN BIASED SIGNALING AT A CLASS A GPCR:

MODELING THE ORG27569 INDUCED CB1/BETA-ARRESTIN 1

COMPLEX.

Dow P. Hurst

, Diane L. Lynch, Derek M. Shore, Michael

C. Pitman, Patricia H. Reggio

490-P

os

B

oard

B270

MOLECULAR DETERMINANTS AND KINETIC PARAMETERS

OF LIGAND BINDING TO G PROTEIN-COUPLED RECEPTORS

USING MARKOV STATE MODEL ANALYSIS.

Sebastian Schneider

,

Davide Provasi, Marta Filizola

491-P

os

B

oard

B271

LCK CLUSTER DYNAMICS IN LIVE CELLS.

Florian Baumgart

,

Andreas Arnold, Gerhard Schütz

492-P

os

B

oard

B272

THE B CELL RECEPTOR DICTATES ITS LOCAL LIPID

ENVIRONMENT.

Matthew B. Stone

, Sarah L. Veatch