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41

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

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612-P

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B

oard

B392

MUTATIONS IN THE S4/S5 LINKER AND S6 OF SLO1 ABLATE

THE RESPONSE TO THE NOVEL BK CHANNEL OPENER

GOSLO-SR-5-6.

Arvind Kshatri

, Tim I. Webb, Roddy J. Large, Adebola

Morayo Akande, Subhrangsu Roy, Gerard P. Sergeant, Noel G. McHale,

Keith D. Thornbury, Mark A. Hollywood

TRP Channels I (Boards B393-B408)

613-P

os

B

oard

B393

A MECHANISM FOR DETECTING THE RATE OF

TEMPERATURE CHANGE IN DROSOPHILA.

Junjie Luo

, Wei L.

Shen, Craig Montell

614-P

os

B

oard

B394

ELECTROPHYSIOLOGICAL CHARACTERIZATION OF

INTERNAL AND EXTERNAL LIGANDS ON TRPA1.

Andrea Bruggemann

, Markus Rapedius, Tom Götze, Claudia Haarmann,

Ilka Rinke, Marius Vogel, Timo Stengel, Johannes Stiehler, Michael

George, Niels Fertig

615-P

os

B

oard

B395

COOLING DOWN TRP CHANNEL: COLD AND CHEMO-

SENSITIVITY OF THE HUMAN TRPA1.

Mohamed Kreir

, Lavanya

Moparthi, Edward D. Högestätt, Urban Johanson, Andrea Bruggemann,

Peter M. Zygmunt, Niels Fertig

616-P

os

B

oard

B396

THE ROLE OF TRPA1 AND TRPV1 CHANNELS IN OROFACIAL

PAIN.

Roberta Gualdani

, Stefania Ceruti, Giulia Magni, Davide Merli,

Lorenzo di Cesare Mannelli, Oscar Francesconi, Barbara Richichi,

Giancarlo la Marca, Carla Ghelardini, Maria Rosa Moncelli, Cristina

Nativi

617-P

os

B

oard

B397

PROBING TEMPERATURE SENSING OF THERMAL TRP

CHANNELS BY CALORIMETRY.

Kiran Andra

, Anoop Saxena,

Beiying Liu, Feng Qin

618-P

os

B

oard

B398

ROLE OF TRPV1 CHANNELS IN GLIOMA CELL VIABILITY AND

SURVIVAL.

Yelena Nersesyan

, Swapna Asuthkar, Kiran K. Velpula,

Xiaohui Sun, Lusine Demirkhanyan, Eleonora Zakharian

619-P

os

B

oard

B399

DIETARY CAPSAICIN AND EXERCISE: ANALYSIS OF A TWO-

PRONGED APPROACH TO COUNTERACT OBESITY.

Vivek Krishnan

, Kevin Fettel, Baskaran Thyagarajan

620-P

os

B

oard

B400

PROTON AS A DUAL REGULATOR FOR TRPV1.

Bo Hyun Lee

, Jie

Zheng

621-P

os

B

oard

B401

UNRAVELING ALLOSTERIC COUPLING MECHANISMS IN THE

TRPV1 CHANNEL.

Andrés Jara-Oseguera

, Kenton J. Swartz

622-P

os

B

oard

B402

MOLECULAR MECHANISM OF TRPV1 ACTIVATION BY

CAPSAICIN. Fan Yang,

Xian Xiao

, Wei Cheng, Wei Yang, Vladimir

Yarov-Yarovoy, Jie Zheng

623-P

os

B

oard

B403

INSIGHT INTO THE STRUCTURE OF TETRAMER HTRPV1

FROM HOMOLOGY MODELING, MOLECULAR DOCKING,

MOLECULAR DYNAMICS SIMULATION AND VIRTUAL

SCREENING.

Zhiwei Feng

624-P

os

B

oard

B404

THE MOLECULAR DETERMINANTS OF PI(4,5)P2 BINDING TO

TRPV1 CHANNELS.

Horacio Poblete

, Ingrid Oyarzún, Pablo Olivero,

Jeffrey Comer, Matías Zuñiga, Romina Sepulveda, David Báez-Nieto,

Carlos González, Ferando Gonzalez-Nilo, Ramón Latorre

625-P

os

B

oard

B405

PREPARATION AND EVALUATION OF PLGA COATED

CAPSAICIN MAGNETIC NANOPARTICLES FOR TARGET SITE-

SPECIFIC PAIN THERAPEUTICS.

Mrudhula Baskaran

, Baskaran

Thyagarajan

626-P

os

B

oard

B406

DISSOCIATION RATES AS ONE OF THE DIFFERENTIATING

FACTORS FOR HYPERTHERMIC AND NON-HYPERTHERMIC

TRPV1 ANTAGONISTS.

Laykea Tafesse

, Gang Wu, Kevin Carlin,

Toshiyuki Asaki, Toshiyuki Kanemasa, Victor Ilyin

627-P

os

B

oard

B407

A SINGLE-RESIDUE SWITCH FOR HIGH TEMPERATURE

DEPENDENCE OF THERMAL TRPV3 CHANNELS.

Beiying Liu

,

Feng Qin

628-P

os

B

oard

B408

THE SPIDER TOXIN GSMTX-4 BLOCKS TRPV4 CATION

CHANNELS EXPRESSED IN HEK-293 CELLS. Christian SJ

Kesselring, Mirjam Krautwald, Yaxin Zhang,

Heinrich Brinkmeier

Ion Channel Regulatory Mechanisms I

(Boards B409-B427)

629-P

os

B

oard

B409

USE-DEPENDENT ACTIVATION OF NEURONAL KV1.2

CHANNEL COMPLEXES.

Victoria A. Baronas

, Brandon R.

McGuinness, Yury Y. Vilin, Robin Y. Kim, Arohumam Kan, Runying

Yang, Harley T. Kurata

630-P

os

B

oard

B410

THE IMPACT OF CHOLESTEROL ON GIRK CHANNELS

DEPENDS ON A TRANSMEMBRANE REGION OF THE

CHANNELS.

Avia Rosenhouse-Dantsker

631-P

os

B

oard

B411

THE SIGNIFICANCE AND MECHANISMS OF CLUSTERING BY

SLC4 COTRANSPORTERS IN THE PLASMA MEMBRANE.

Harry Gill

632-P

os

B

oard

B412

THE ROLE OF ROS IN TETHERING CFTR WITHIN CERAMIDE

PLATFORMS AT THE PLASMA MEMBRANE.

Asmahan AbuArish

,

Paul W. Wiseman, John W. Hanrahan

633-P

os

B

oard

B413

REFINEMENT AND EVALUATION OF A CFTR HOMOLOGY

MODEL AND IDENTIFICATION OF RESIDUES CONTROLLING

CHANNEL GATING. Gorman Stock, Guiying Cui, Nael A. McCarty,

James C. Gumbart

634-P

os

B

oard

B414

SOLUTION NMR TO INVESTIGATE GATING IN THE NAK

CHANNEL.

Joshua Brettmann

, Andrew Meiburg, Katherine Henzler-

Wildman

635-P

os

B

oard

B415

A NEW CLASS OF POSITIVE GATING MODULATORS OF

HKV3.2 CHANNELS: INSIGHTS INTO THE MECHANISM OF

ACTION.

Qiansheng Liang

, Giuseppe Alvaro, Charles Large, Manuel

Covarrubias