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45

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

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708-P

os

B

oard

B488

PERSISTENT ACTIVATION OF SIGNAL TRANSDUCTION

NETWORKS INDUCES A NOVEL MECHANISM OF CELL

DEATH.

Marc Edwards

, Huaqing Cai, Peter Devreotes

709-P

os

B

oard

B489

ACUTE MECHANICAL STIMULATION ACTIVATES THE

CHEMOTACTIC SIGNALING NETWORK.

Yulia Artemenko

, Jane

S. Borleis, Peter N. Devreotes

710-P

os

B

oard

B490

PHARMACOLOGICAL ACTIVATION OF MYOSIN II TO

CORRECT PANCREATIC CANCER CELL MECHANICS.

Alexandra Surcel

, Qingfeng Zhu, Eric Schiffhauer, Robert Anders,

Douglas Robinson

711-P

os

B

oard

B491

SH3 DOMAIN OF C-SRC REGULATES ITS DYNAMIC BEHAVIOR

IN THE CELL MEMBRANE.

Hiroaki Machiyama

, Tomoyuki

Yamaguchi, Tomonobu M. Watanabe, Hideaki Fujita

712-P

os

B

oard

B492

INSIGHTS ON RGD-BASED PEPTIDE INTERACTIONS

WITH INTEGRIN RECEPTORS FROM ATOMISTIC

SIMULATIONS.

Aravind Rammohan

, Jacob Miner, Matthew Mckenzie

713-P

os

B

oard

B493

H2-CALPONIN GENE KNOCKOUT INCREASES TRACTION

FORCE OF MOUSE FIBROBLASTS IN VITRO.

M Moazzem Hossain

, Guangyi Zhao, Moon-Sook Woo, James H-C.

Wang, J.p. Jin

714-P

os

B

oard

B494

education

travel awardee

DELETION OF H2-CALPONIN IN MACROPHAGES

FACILITATES CELL MOTILITY AND LIPID CLEARANCE:

A NOVEL MECHANISM TO ATTENUATE ARTERIAL

ATHEROSCLEROSIS.

Rong Liu

, Jian-Ping Jin

Membrane Pumps, Transporters, and

Exchangers I (Boards B495-B515)

715-P

os

B

oard

B495

ARRAYED LIPID MEMBRANES ON FEMTOLITER

CHAMBERS ALLOW HIGHLY SENSITIVE DETECTION OF

ION TRANSLOCATION CATALYZED BY TRANSPORTER

PROTEIN.

Rikiya Watanabe

, Naoki Soga, Hiroyuki Noji

716-P

os

B

oard

B496

VOLTAGE DEPENDENT CONFORMATIONAL CHANGES

OF THE NA

+

/K

+

-ATPASE REVEALED BY SITE DIRECTED

FLUOROMETRY.

Jorge E. Sánchez-Rodríguez

, Pablo Miranda-

Fernández, Miguel Holmgren, Francisco Bezanilla

717-P

os

B

oard

B497

NA

+

/K

+

-ATPASE PUMPING MECHANISM: INSIGHTS FROM

SIMULATIONS.

Huan Rui

, Avisek Das, Benoit Roux

718-P

os

B

oard

B498

TOWARDS THERMODYNAMIC CHARACTERIZATION OF

TRANSPORT CYCLE IN SECONDARY TRANSPORTERS USING

ENHANCED SAMPLING TECHNIQUES.

Mahmoud Moradi

, Giray

Enkavi, Emad Tajkhorshid

719-P

os

B

oard

B499

PROTONATION STATES OF KEY ACIDIC RESIDUES

AT THE ION BINDING SITES IN NA/K PUMP BY QM

CALCULATIONS.

Naoki Tsunekawa

, Chikashi Toyoshima

720-P

os

B

oard

B500

education

travel awardee

NA

+

/K

+

PUMP ION BINDING SITE INTERACTIONS REGULATE

THE PROTON LEAK PATHWAY.

Kevin Stanley

, Craig Gatto, Pablo

Artigas

721-P

os

B

oard

B501

POTASSIUM REGULATION OF THE NAK-ATPASE PUMP

CURRENTS IN MAMMALIAN SKELETAL MUSCLE

FIBERS.

Marino G. Di Franco

, Jerry Lingrel, Judith Heiny

722-P

os

B

oard

B502

A COMBINATION OF CURCUMIN WITH EITHER

GRAMICIDIN OR OUABAIN SELECTIVELY KILLS CELLS THAT

EXPRESS THE MULTIDRUG RESISTANCE-LINKED ABCG2

TRANSPORTER.

Haiyan Liu

, Divya K. Rao, Suresh V. Ambudkar,

Michael Mayer

723-P

os

B

oard

B503

education

travel awardee

CONFORMATIONAL CHANGES AND COMPLEX

FORMATION OF THE NON-CANONICAL RIBOSE ABC

TRANSPORTER.

Satchal K. Erramilli

, Cynthia V. Stauffacher

724-P

os

B

oard

B504

MOVEMENT OF THE NUCLEOTIDE BINDING DOMAINS

IN THE ABC TRANSPORTER MSBA RECONSTITUTED IN

NANODISCS.

Maria E. Zoghbi

, Guillermo A. Altenberg

725-P

os

B

oard

B505

MULTISCALE QM/MM SIMULATIONS OF ATP HYDROLYSIS

MECHANISM IN ABC-TRANSPORTERS.

Jingzhi Pu

726-P

os

B

oard

B506

education

travel awardee

RECONSTITUTION OF MULTIDRUG RESISTANCE EFFLUX

PUMPS IN GIANT LIPOSOMES.

SooHyun Park

, You Jung Kang,

Sheereen Majd

727-P

os

B

oard

B507

EXPLORING P-GLYCOPROTEIN SUBSTRATE ACCESS.

Laura Domicevica

, Philip C. Biggin

728-P

os

B

oard

B508

METHIONINE IMPORTERS IN SOIL BACTERIA: POTENTIAL

FOR TRANSPORTER-COMPONENT CROSSTALK.

Eliza Zielazinski

, Sarah Zerbs, Peter Larsen, Frank Collart, Philip D.

Laible

729-P

os

B

oard

B509

EPR ACCESSIBILITY MEASUREMENTS OF THE SERCA-PLB

COMPLEX USING SITE-DIRECTED SPIN LABELING.

Peter D. Martin

, Zachary M. James, Jesse E. McCaffrey, Dave D. Thomas

730-P

os

B

oard

B510

MAPPING OF SARCOLIPIN CONFORMATIONAL STATES

ALONG THE ENZYMATIC PATHWAY OF SERCA.

Alysha A. Dicke

,

Kaustubh R. Mote, Gianluigi Veglia

731-P

os

B

oard

B511

USING A LIVE-CELL HIGH-THROUGHPUT TIME-RESOLVED

FRET ASSAY TO DISCOVER ENZYME MODULATORS.

Ji Li

,

Tory M. Schaaf, Simon J. Gruber, Razvan L. Cornea, Joseph M. Autry,

Samantha L. Yuen, Ryan Chen, Kurt C. Peterson, Gregory D. Gillispie,

David D. Thomas

732-P

os

B

oard

B512

MOLECULAR DYNAMICS SIMULATIONS OF CALCIUM PUMP

STRUCTURAL DISORDER.

Nikolai Smolin

, Seth Robia