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Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
585-P
os
B
oard
B365
STATE DEPENDENT PHOTO-CROSSLINKING OF
THE IKS CHANNEL COMPLEX DEMONSTRATES
MOVEMENT OF KCNE1 AT PRE-OPENING MEMBRANE
POTENTIALS.
Christopher I. Murray
, Maartje Westhoff, Yasmeen
Maurice, Jodene Eldstrom, David Fedida
586-P
os
B
oard
B366
TESTING THE HYDRATION STATUS OF THE SHAKER-K
CHANNEL VOLTAGE SENSOR DOMAIN WITH SUGARS.
Ignacio Díaz-Franulic
, David Naranjo
587-P
os
B
oard
B367
THE EFFECT OF D2O ON THE INACTIVATION KINETICS AND
RECOVERY FROM SLOW INACTIVATION OF SHAKER-IR K
+
CHANNELS. Tibor G. Szanto, Orsolya Szilagyi,
Gyorgy Panyi
588-P
os
B
oard
B368
NON-CANONICAL START CODONS REINITIATE
TRANSLATION IN N-TERMINAL TRUNCATED KV
CHANNELS.
Tanja Kalstrup
, Rikard Blunck
589-P
os
B
oard
B369
ACTIVATION GATE REGION INFLUENCES STOICHIOMETRY
OF HETEROMERIC SHAKER FAMILY CHANNELS.
Aditya Pisupati
, William J. Horton, Keith Mickolajczyk, Xiaofan Li, Jose
Chu, William O. Hancock, Timothy Jegla
590-P
os
B
oard
B370
ION PERMEATION IN POTASSIUM CHANNELS INVOLVES
DIRECT COULOMB KNOCK-ON BETWEEN IONS.
Ulrich
Zachariae
, David A. Kopfer, Chen Song, Tim Gruene, George M.
Sheldrick, Bert L. de Groot
591-P
os
B
oard
B371
DYNAMICS OF THE KCSA SELECTIVITY FILTER PROBED
USING INTRINSIC TYROSINE FLUORESCENCE.
H Raghuraman
,
Eduardo Perozo
592-P
os
B
oard
B372
ROLE OF THE S6-PXP MOTIF IN U-TYPE INACTIVATION OF
HETEROTETRAMERIC KV2.1/KV6.4 CHANNELS.
Jeroen I. Stas
,
Elke Bocksteins, Alain J. Labro, Dirk J. Snyders
593-P
os
B
oard
B373
VOLTAGE DEPENDENCE OF BK CHANNELS GATING RING
MOTION STUDIED BY STATE DEPENDENT FRET.
Pablo Miranda
, Teresa Giraldez, Miguel Holmgren
594-P
os
B
oard
B374
QUANTITATIVE MAPPING OF INTERACTIONS IN THE
VOLTAGE-SENSOR PORE INTERFACE OF THE SHAKER
POTASSIUM CHANNEL.
Kevin Oelstrom
, Ana Fernandez-Mariño,
Baron Chanda
595-P
os
B
oard
B375
BINDING OF QUATERNARY AMMONIUM IONS TO A
POTASSIUM CHANNEL.
Dylan O. Burdette
, Adrian Gross
596-P
os
B
oard
B376
STRUCTURE AND DYNAMICS OF THE MTHK K
+
CHANNEL
SELECTIVITY FILTER DURING GATING.
David J. Posson
, Céline
Boiteux, Toby W. Allen, Crina M. Nimigean
597-P
os
B
oard
B377
RECONSTITUTION AND MEASUREMENT OF ION CHANNEL
ENSEMBLES IN DROPLET BILAYERS.
Viksita Vijayvergiya
, Shiv
Acharya, Jacob Schmidt
598-P
os
B
oard
B378
THE CONFORMATION OF KCSA’S SELECTIVITY FILTER
INFLUENCES THE OPENING OF ITS ACTIVATION
GATE.
Cholpon Tilegenova
, D. Marien Cortes, Luis G. Cuello
599-P
os
B
oard
B379
ENGINEERING HERG CHANNEL INNER CAVITY WITHIN
KCSA STRUCTURE.
Luis G. Cuello
, D. Marien Cortes
600-P
os
B
oard
B380
PIP2 MODIFIES THE FREE ENERGY OF THE KV1.2 VOLTAGE-
SENSOR ACTIVATION.
Marina A. Kasimova
, Lucie Delemotte,
Michael L. Klein, Vincenzo Carnevale, Mounir Tarek
601-P
os
B
oard
B381
K
+
-DEPENDENT SELECTIVITY AND EXTERNAL CALCIUM
BLOCK OF SHAB POTASSIUM CHANNELS.
Froylan Gomez-Lagunas
, Elisa Carrillo
602-P
os
B
oard
B382
TIME-DEPENDENT VOLTAGE SENSOR RELAXATION IN HERG
CHANNELS.
Samrat Thouta
, Yu Patrick Shi, Stanislav Sokolov, Yen May
Cheng, Tom W.Claydon
603-P
os
B
oard
B383
BLOCK OF HERG BY EXTRACELLULAR CALCIUM AND OTHER
DIVALENT IONS. Andrew Nguyen, Alice Wong, Angad Oberoi,
Thuyvy Le,
Alan Miller
604-P
os
B
oard
B384
EXTERNAL PROTONS DESTABILIZE THE RELAXED STATE OF
THE HERG CHANNEL VOLTAGE SENSOR.
Yu Patrick Shi
, Samrat
Thouta, Yen May Cheng, Tom W. Claydon
605-P
os
B
oard
B385
NOVEL VOLTAGE PROTOCOLS FOR DETERMINING HERG
CHANNEL KINETICS.
Gary R. Mirams
, Kylie Beattie, James B.
Louttit, Teun de Boer, David J. Gavaghan
606-P
os
B
oard
B386
STOICHIOMETRY OF A HERG1 AGONIST ON CHANNEL
GATING.
Wei Wu
, Alison Gardner, Frank Sachse, Michael Sanguinetti
607-P
os
B
oard
B387
MOLECULAR ORIGINS OF STATE-DEPENDENT HERG1
BLOCKADE BY DOFETILIDE.
Yibo Wang
, Laura Perissinotti, Jiqing
Guo, Henry J. Duff, Sergei Yu. Noskov
608-P
os
B
oard
B388
THE ROLE OF MET-691 IN HEME-DEPENDENT REGULATION
SUPPORTS THE PRESENCE OF A CYTOCHROME-C-LIKE
STRUCTURE IN HUMAN BK CHANNELS.
Taleh Yusifov
, Nicoletta
Savalli, Saemi Park, Antonios Pantazis, Riccardo Olcese
609-P
os
B
oard
B389
THE HEME-BOUND HUMAN BK CHANNEL GATING RING IS
A CO SENSOR.
Taleh Yusifov
, Nicoletta Savalli, Stefan H. Heinemann,
Toshinori Hoshi, Riccardo Olcese
610-P
os
B
oard
B390
A NOVEL APPROACH FOR LOCATING THE SITES OF DRUG
ACTION ON BK CHANNELS.
Yanyan Geng
, Alice Butler, Lawrence
B. Salkoff, Karl M. Magleby
611-P
os
B
oard
B391
CADMIUM COORDINATION BY CYSTEINES INTRODUCED
IN THE BK INNER PORE AND ITS STRUCTURAL AND
FUNCTIONAL IMPLICATIONS.
Yu Zhou
, Xiaoming Xia, Christopher
J. Lingle