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TRG , ypT & ypN stage
ypT0
ypT1
ypT2
ypT3
ypN0
ypN1/2
•
131 resectable cT3/T4 rectal carcinomas treated with CRT ( polish RCT of SCRT
versus pre-op CRT )
TRG 0 : no cancer cells present
TRG 1 : a few cancer foci ( < 10% of tumor mass )
TRG 2 : residual cancer representing 10 – 50 % of tumor mass
TRG 3 : residual cancer representing > 50 % of tumor mass
TRG 0
22
( 100% )
20
( 95% )
1
( 5 % )
TRG 1
7
( 17% )
25
( 63 % )
8
( 20 % )
31
( 77 % )
9
( 23 % )
TRG 2
1
( 3 % )
13
( 32 % )
26
( 65 % )
22
( 55 % )
18
( 45 % )
TRG 3
4
( 14 % )
10
( 34 % )
15
( 52 % )
15
( 54 % )
13
( 46 % )
( Bujko et al 2010 )
ypT stage best predictor of nodal status in multivariate analysis :
OR 4.66 for ypT2 & 12.06 for ypT3 versus ypT0/1.