447 / 1068
TRG & SURVIVAL AFTER
CHEMORADIOTHERAPY
• 126 patients 1997 – 2007 with cT3-4 or cN1/2
disease treated with 45-50 Gy plus 5FU prior to
surgery
• Mandard grades used with simplification to 3
categories :
mandard 1 & 2 = TRG 1
mandard 3 = TRG 2
mandard 4 & 5 = TRG 3
Tumour downstaged in 60 % cases
TRG 1 : 21 % TRG 2 : 39 % TRG 3 : 40 %
Local recurrence rate all cases : 7 %
5 yr disease free and overall survival all cases : 72 % and 63 %
Beddy et al 2008