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Prognostic Value of TRG after CRT for Rectal
Cancer : CAO/ARO/AIO-94 TRIAL
N Node pos 5yr LR 5yr met free
Survival
5yr DFS
TRG 0 + 1 75 41% 6% 66% 63%
* p = 0.33
** p = 0.009
*** p = 0.006
TRG 0: no
regression
TRG 2 + 3 229 32% 4% 75% 75%
TRG 4
40 10% 0%* 86%**
86%**
TRG 1: fibrosis <
25% tumor mass
TRG 2: fibrosis
25-50% tumor
mass
TRG 3: fibrosis >
50% tumor mass
TRG 4: complete
regression
ypT & ypN stage still most important prognostic
factors for DFS on multivariate analysis !
Rodel et al 2005