450 / 1068
CAO/ARO/AIO-94 Trial
N = 386
Median F.U. 132 months
TRG % 10 yr
DM rate
10 yr DFS
TRG 0+1 23.3% 39.6% 63%
TRG 2+3 66.3% 29.3% 73.6%
TRG 4 10.4% 10.5% 89.5%
HR for TRG in multivariate
analysis :
0.74 for DM
0.76 for DFS
p < 0.04
( Fokas et al 2014 )