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ESTRO BCR Course / NT radiosensitivity and fractionation – W. Dörr

Tissue/reaction

a/b

-value

[Gy]

-

Ref.

Epidermis

Desquamation

9.1-12.5

8.6-10.6

9-12

49.6 [42.2;58.6]

Douglas and Fowler 1976

Joiner et al. 1983

Moulder and Fischer 1976

Ruifrok et al. 1994

Oral

mucosa

Ulceration

7.9 [1.8;25.8]

10.8

7.4

16.4 [14.6;18.2]

11.6 [6.8;18.9]

11.9 [7.4;20.2]

Ang et al. 1985

Moses and Kummermehr 1986 (Reanalysis)

Scalliet et al. 1987

Stüben et al. 1991

Dörr et al. 1993

Nickstadt and Dörr, unpublished

Intestine

Crypt survival

Weight loss

6.0-8.3

6.6-10.7

8-9

13.3

9-13-

Withers et a. 1976

Thames et al. 1981

Tucker et al. 1983

Huczkowski and Trott 1984

Tucker and Denekamp 1984

Urinary bladder

Impaired function

13.9 [8.4;24.6]

11.0 [7.5;16.1]

Dörr and Schultz-Hector 1992

Dörr 1995

Testis

clon. survival

12-13

Thames and Withers 1980

a/b

-value

- early effects / experimental data

Dose fractionation: LQ formalism