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Contribution of minor folates to the total folate content of infant formula and

adult/pediatric nutritionals / F. Martin (NRC, AS)

03 Feb 2016

CONFIDENTIAL

ͼ This document may not be reproduced or disclosed to third parties without prior authorization

Page 7 / 13

R E S U L T S

Contribution of monoglutamate forms of folates to the total vitamin B9 content

The only form of folate above quantitation limit (LOQ= 0.1 μg/100 g RTF) was 5ͲMeͲTHF, with

contribution to the total folate varying from 0 to 14 %. The results are compiled in the following table.

Table 1

: Folic acid and 5MeTHF monoglutamate in infant formulas and adult/pediatric nutritionals.

Results of duplicate analysis.

Folic Acid (μg/100 g RTF)

5MeTHF (μg/100 g RTF)

Avg

SD CV

Avg

SD

CV

MilkͲbased infant formula

19.6 0.44 2.3% 0.9

0.00 0.5%

SoyͲbased infant formula

17.3 0.12 0.7% BLOQ

Infant formula powder, partially

hydrolyzed milkͲbased

16.2 0.29 1.8% BLOQ

Infant formula powder, partially

hydrolyzed soyͲbased

19.5 0.31 1.6% BLOQ

Adult nutritional ready to feed –

high fat

73.2 0.56 0.8% BLOQ

Adult nutritional ready to feed –

high protein

56.8 0.70 1.2% BLOQ

MilkͲbased toddler Formula powder 13.8 0.08 0.6% 2.0

0.00 0.1%

Milk based Infant formula powder

13.3 0.17 1.3% BLOQ

Infant formula ready to feed – milkͲ

based

19.9 0.64 3.2% 0.6

0.02 4.4%

SRM 1849a

23.9 0.32 1.3% 0.9

0.02 2.1%

Child formula powder – milkͲbased 43.1 1.55 3.6% 1.5

0.07 4.8%

LowͲFat adult nutritional powder

37.2 0.20 0.5% BLOQ

Infant elemental powder

30.6 0.76 2.5% BLOQ

Infant formula powder – FOS/GOS

based

10.0 0.49 4.9% 0.8

0.02 2.2%

Contribution of the folic acid and the 5ͲMeͲTHF are graphically represented in the next page.

2013.13 (Fol-21) / (February 2016) - NOTES

FOR ERP USE ONLY

DO NOT DISTRIBUTE