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Contribution of minor folates to the total folate content of infant formula and
adult/pediatric nutritionals / F. Martin (NRC, AS)
03 Feb 2016
CONFIDENTIAL
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Page 13 / 13
C O N C L U S I O N
When analysis minor folates using a modified AOAC 2013.13 to include other folate forms, no minor
folates, apart from 5ͲMeͲTHF were able to be quantified.
The addition of a deconjugase step did liberate minor folates, indicating the presence of some
polyglutamate forms. When focusing on 5ͲMeͲTHF, as mentioned in the SMPR, the impact on the total
vitamin B9 is particularly low
: 1.0 % in average
.
Other minor folate polyglutamates not mentioned in the SMPR are present mainly in the soy based
products (around 10 % of total folates). They represent in average 2.4 %. When excluding soyͲbased
products, they represent only 1.2 % of the total folates contribution.
D I S T R I B U T I O N
Name, Location
Name, Location
Name, Location
SPIFAN Expert Review Panel
E. Konings, NRC FSQ
R. Bowling, NRC AS
Vitamins & Phytonutrients
group
2013.13 (Fol-21) / (February 2016) - NOTES
FOR ERP USE ONLY
DO NOT DISTRIBUTE