Palliative care 2017

Radiotherapy in gastric bleeding

• There was

no difference

in response rate of bleeding between regimens

with high BED of ≥ 39Gy versus regimens with low BED < 39Gy

• Thus,

low dose regiments

1 x 8Gy, 5 x 4Gy, 10 x 3Gy, 3 x 6Gy most

beneficial and repeatable

(Kawabata, H, J Palliat Med 2017)

• Conflicting results

(Lee Y, BMC Cancer 2017)

, BED10 >36Gy most

significant factor for EBRT response for gastric bleeding

• Grade 3 to 4

toxicities

occurred in up to 15% of patients when treated

with RT alone and up to 25% of patients treated with

chemoradiotherapy:

gastritis, anorexia, neutropenia

• Health-related quality of life (HRQL) outcomes

were not reported

JK 30/49