990 / 1224
CCA TREATED RADICALLY
AUTHOR
DESIGN
LOCATION
NUMBER OF
PATIENTS
RT DOSE SCHEME±
CHEMOTHERAPY
2y
LOCAL CONTROL
2y /MEDIAN
SURVIVAL
Tse
2008
Phase I
Intra-hepatic
10
6x4-9Gy
No chemo
65%*
at 1 y
58%
at 1y
15
Months
Momm
2010
Retrospective
Perihilar
13
32-56Gy in
3-4Gy per fraction
6/13 Chemo
Not reported
67%
23.6
Months
Kopek
2010
Retrospective
Intra-hepatic
Perihilar
1
26
3x15Gy
(at isocenter)
No chemo
84%
at 1 y
15%
10.6
Months
Polistina
2011
Prospective
Perihilar
10
3x10Gy
10/10 chemo
Not reported
80%
35.5
Months
Barney
2012
Retrospective
Intra-hepatic
Perihilar
**Extrahepatic:
Adrenal gland
6
3
1
45-60Gy in
3-5 fractions
8 chemo
100%
73%
at 1 y
Not reported
Mahadevan)
2015
Retrospective
Intra-hepatic
Perihilar
Intra-+extra-
hepatic
31
2
9
10-45Gy in
3-5 fractions
18 chemo
79%
31%
17
Months
Tao
2016
Retrospective
Intra-hepatic
79
50.4-75Gy
in 15-30 fractions
75 chemo
BED≤80.5Gy
3y 45%
>80.5Gy
3y 78%
61%
30
Months