993 / 1224
SUSCEPTIBILITY HEPATIC TOXICITY
•
Main issue for HCC
•
Biological factors:
- Preexisting/ severity liver cirrhosis (Child Pugh B > A)
- Hepatitis virus B carrier status
•
Physical factors:
- Mean liver dose
- Liver volume receiving <18 Gy in 3 fractions (>800cc)
- Low dose-volumes in Child B patients
•
Tumor factors: ≥ 35mm