SUSCEPTIBILITY HEPATIC TOXICITY
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Main issue for HCC
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Biological factors:
- Preexisting/ severity liver cirrhosis (Child Pugh B > A)
- Hepatitis virus B carrier status
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Physical factors:
- Mean liver dose
- Liver volume receiving <18 Gy in 3 fractions (>800cc)
- Low dose-volumes in Child B patients
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Tumor factors: ≥ 35mm