87 / 1084
Preoperative
Chemoradiation
Planned Esophagectomy
• Walsh et al – 1996
• Urba et al – 2001
• Burmeister et al – 2005
Preoperative
Chemoradiation
Planned Esophagectomy
Mid-Distal 92% 100 pts Adeno 75%
EQD2: 48.75 Gy
Cardia 36% 113 pts Adeno 100%
EQD2: 42.33 Gy
Mid-Distal 79% 256 pts Adeno 62%
EQD2: 36.17 Gy
Tumor site
N. Histology
EQD2
• CROSS - 2015
• Tepper et al – 2008
• FFCD 9901 – 2014
Mod from Cellini
et al
; Radiat Oncol 2014
(Italy)
Low third
n.a.
56 pts Adeno 75%
EQD2: 49.56 Gy
Below carina 91% 194 pts Adeno 29%
EQD2: 44.25Gy
Junction 24% 366 pts Adeno 75%
EQD2: 40.71 Gy
Statistically in favour of Preop ChemoRT