72 / 154
6. Based on the supporting
information, what are the cons
/weaknesses of the method?
No tinctures or liquids were tested. Would like to see demonstration of method on
these types of products to meet SMPR.
Method was not tested in the presence of carotenoids, piper nigrum, or Ca. Would
like to see demonstration of method on products including these to meet SMPR.
Would prefer an internal standard approach to the external standard approach
presented here.
No recovery data ‐ would need recovery data to meet SMPR.
Several concerns about extraction optimization. 100% methanol gives 10%+ better
extraction efficiency, yet 80:20 methanol:water was selected. Also, additional
curcuminoids are being extracted in 2nd‐4th extractions. This could be because
80:20 methanol:water is not as effective as 100% methanol, but would like to see
the same study with 100% methanol.
7 . Any general comments about
the method?
No
Do you recommend this method be
adopted as a First Action and
published in the Official Methods
of Analysis of AOAC
INTERNATIONAL? Please specify
rationale.
Not at this time. I think significant work is needed on the extraction protocol and
more products need to be explored before this method could be First Action.
V. Recommendation for the Method