70 / 154
Reviewer Name:
Melissa Phillips
Email:
melissa.phillips@nist.govOrganization:
NIST
Method Reviewed:
TUR‐02
Method Title:
Quantitation of Curcuminoids
Applicable SMPR
2016.003
Summary of Method:
An 80:20 methanol:water extraction followed by LC‐absorbance for determination of
CUR, BDMC, and DMC in turmeric materials. Optimization of some extraction
parameters was discussed.
1. Does the Applicability of the
Method Support the Applicability
of the SMPR? If not, please explain
what is missing.
Yes
2. Does the analytical technique(s)
used in the method meet the
SMPR? If not, please specify how it
differs from what is stated in the
SMPR.
Yes
3. Are the definitions specified in
the SMPR used and applied
appropriatly in the method? If no,
please indicate how the terms are
used.
Yes
4. Does the method, as written,
contain all appropriate precautions
and warnings related to the
method's regaents, components,
instrumentation, or method steps
that may be hazardous? If no,
please suggest wording or
option(s).
No safety information is included. Could potentially include a statement regarding
flammability of solvents, acidity of mobile phase, as well as use of elevated column
temperature, but this is not critical.
1. Are the definitions specified in
the SMPR used and applied
appropriately in the supporting
documentation (manuscripts,
method studies, etc…)? If not,
please explain the differences and
if the method is impacted by the
difference.
Yes
2. Is there information
demonstrating that the method
meets the SMPR Method
Performance Requirements using
the Reference Materials stated in
the SMPR? If not, then specify
what is missing and how this
impacts demonstration of
performance of the method.
Reference standards were acquired from a different vendor (Chromadex) than those
listed in the SMPR; purity of standards should be evaluated and confirmed or
corrected in‐house.
Matrix reference materials listed in SMPR were not used in this study (although they
are not yet available from NIST).
General Information
I. Summary
II. Review of the Method Only
III. Review of Information in Support of the Method