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Atkinson et al. Qual Life Res 2012

N=393 patients, mixed cancer type

CTCAE assessed by 2 independent physicians within ~1h

Results in symptomatic patients

15-43% agreement

51-70% 1 grade differences

1-18% 2 grades differences

CTCAE agreement between

2 physicians is moderate at best!

The lower the CTCAE grading, the more variation between physicians is observed.

Disagreement mainly between G0/G1/G2.

Chinnachamy et al. Jpn J Clin Oncol 2013

Inter-rater reliability of CTCAE

morbidity assessment