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J
IANMING
T
AO
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jtao@spectrixservices.comP
ROFESSIONAL
E
XPERIENCE
Roswell Park Cancer Institute,
Buffalo, NY
2003 – 2005
Research Associate
•
Led projects on: (1) the mechanism of T-cell trafficking and developing in murine allergic
bronchopulmonary aspergillosis (ABPA) model; (2) the effect of IL-21 on antigen specific naïve CD8+
T cell activation, proliferation, differentiation, effector function, and memory cell formation in a T-cell
transferred mouse model.
Case Western Reserve University,
Cleveland, OH
2001 – 2003
Research Associate
•
Initiated and conducted in-depth study on the cytokine and chemokine relationship in the murine
GvHD model of human scleroderma and engineered cell therapy.
Cleveland Clinic Foundation,
Cleveland, OH
2000 – 2001
Research Fellow
•
Investigated the effects of alternated structure of DNA polymerase beta on human breast, lung,
and colorectal cancers.
CIB-CSIC,
Madrid, Spain
1994 – 2000
Graduate Research Assistant
•
Developed the mutation detection method, PCR single-stranded conformation polymorphism (PCR-
SSCP), as a routine tool in laboratory.
•
Elucidated the structure-function relationship of intergrin alphaIIb-beta3 by studying molecular-genetic
basis of human inherited platelet disease, Glanzmann thrombasthenia, and through comparison of
cDNA sequences for species integrins alphaIIb and beta3 with that of human counterparts.
ECUST,
Shanghai, China
1989 – 1994
Engineer
•
Studied inosine fermentation by an inosine-producing auxotroph of a B.subtilis strain.
•
Optimized the fermentation process of penicillin by computer-aided design and control in industrial scale.
•
Developed an immobilization method for whole cell of Methanotroph Z201 for converting propylene
to propylene oxide.
•
Studied the cultivation of B. subtilis DB403 (pNC3) cloned neutral protease gene (nprE).
•
Screened and improved the strain of B. subtilis for high-yield inosine.
•
Optimized the fermentation process for production of atrial natriuretic polypeptide by a recombinant
yeast Y33::YFD71-3.
•
Developed high cell density cultivation with high level of expression of recombinant human interferon
Gamma by DH5alpha E. coli (pBV220A) harboring target gene.
•
Studied and supported the manufacture of RIBE-6 5-litre semi-automatic laboratory fermenter.
•
Researched interferon alpha A production by cultivation of E. coli W3110(pEC901) cloning an
interferon alphaA gene.
AOAC OMB Meeting Book
267