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Combination of conventional

radiotherapy & targeted drugs

Ø

Relevant and increased risk of severe toxicity

Vemurafenib

Schulz Strahlentherapie Onkologie 2014

Award Clinical Oncology 2016

Erlotinib

07.09.17

ESTRO SBRT COURSE 2017 - Matthias Guckenberger

37

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Stereotactic radiotherapy

Ø

Very high doses in gross tumor volume

Ø

Very high doses in small normal tissue volumes

Ø

Intermediate doses in only small normal tissue volumes

Ø

Low doses in large normal tissue volumes

07.09.17

ESTRO SBRT COURSE 2017 - Matthias Guckenberger

38