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Timing of RT and immunotherapy
Ø
Sequencing of RT and immunotherapy relevant
Ø
Concurrent application
A – Start of RT
B – End of RT
C – after RT
concurrent
sequential
Dovedi Cancer Res 2014
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Combination of RT with immunotherapy
Ø
Relevant complete response rates only after
radiotherapy and double checkpoint inhibition
PDL1 C4 & PDL1
C4 & PD1
RT & C4 & PD1 / PDL1
CR
0% 0% 20%
80%
Twyman-Saint Victor Nature 2015
Melanoma mouse model