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Combination of RT with immunotherapy
Ø
High „cure” rates only after RT & double CPI
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Reproducible in melanoma & pancreatic cancer model
Twyman-Saint Victor Nature 2015
Melanome mouse model
Pancreatic cancer mouse model
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Proof of principle:
Golden Lancet Oncol 2015
Inclusion criteria:
• Stable or progressing metastatic solid tumours
• At least three distinct measurable sites of disease
• On single-agent chemotherapy or hormonal therapy
•
80% NSCLC & Breast
cancer
•
RT 10 x 3,5Gy
•
2 targets irradiated
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