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Abscopal effect
07.09.17
ESTRO SBRT COURSE 2017 - Matthias Guckenberger
21
•
Systemic
tumor response induced by
local
radiotherapy
„ab-scopus“
: away from the target
/
Cancer cell: immunogenic cell death
07.09.17
ESTRO SBRT COURSE 2017 - Matthias Guckenberger
22
Ø
„ICD constitutes a prominent pathway for the activation of
the immune system against cancer, which in turn determines
the long-term success of anticancer therapies“
Kroemer Annual Review of Immunology 2013
• Changes in the composition of
the cell surface
• Release of soluble mediators
Ø
Increased presentation of
tumor antigens to T-cells via
dentitic cells