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Maximizing immunogenic effect of RT
Ø
How can we influence and maximize the
immunogenic effect of radiotherapy?
Abuodeh Curr Probl Cancer 2016:
Ø
46
reported cases from 1969 to 2014
Insufficient
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ESTRO SBRT COURSE 2017 - Matthias Guckenberger
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Dewan Clin Cancer Res 2009
Fractionation of RT
Ø
Abscopal effect induced by hypo-fractionated and
not single fraction RT combined with anti–CTLA-4
0Gy
1 x 20Gy
3 x 8Gy
6 x 6Gy
Irradiated tumor
Un-irradiated tumor
Breast and colon
cancer mouse model