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Radiotherapy: WBRT
standard of care with the goal of short-term palliation
- Typical indication:
multiple brain metastases
- 30 Gy in 10 fractions or 37.5 Gy in 15 fractions or 20Gy in 5
fractions is considered “standard” dose for WBRT
- Patients with life aspectancy < 3-6 months 20 Gy in 5 fractions
- Leptomeningeal tumor extension
- WBRT regimens demonstrate median survivals 15-18 weeks
Significant risk for
neurocognitive decline
due to damages to
the brain parenchyma or induction of intracerebral vascular
changes