Framebased-Frameless_DV_2017

Total

(n=1194)

1 tumors

N=455

2-4 tumors

(B) N=531

5-10

tumors

(C) N=208

P value

B vs C

Died

Neurological death

850 (71%)

71(8%)

310 (68%)

32(10%)

392(74%)

25 (6%)

148(71%)

14(9%)

0.46

0.27

Deterioration of

neurological function

146 (12%) 56(12%)

62 (12%)

28(13%)

0.53

Local recurrence

138 (13%) 65(16%)

54 (11%)

19(10%)

0.78

New lesions

625 (58%) 199 (48%) 297 (63%) 129 (69%) 0.12

•

Treatment with SRS with up to 10 brain metastases is feasible without

significant higher number of new brain lesions and local recurrences

than in the group of 2-4 metastases.