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IMRT / VMAT with SIB in Patients with Brain Oligometastases
Author
Endpoint
PTV wb/dose
PTV m/dose
Cases
(lesions)
Main findings
Bauman
2007
WBRT +SIB (HT) vs
WBRT + conventional
SRT
30 (60)
14 (1-3)
SIB HT is a feasible alternative for SRT
on small volume
Edwards
2010
WBRT + SIB(HT)
30 (40)
11 (1-4)
WBRT + SIB (HT) is feasible without
adverse effects
Hsu
2010
WBRT + SIB (VMAT) vs
SRT
32.23 (63-70.8)
10 (1-3)
SIB-VMAT plans achieve adequate
WBRT coverage with conformal
hippocampal avoidance and RS quality
dose distributions
Rodrigues
2011
WBRT+
SIB (HT)
30 (35-60)
48 (1-3)
60 Gy in 10 fract. To 1-3 brain
metastases synchronously with 30 Gy
WBRT
Nichol
2016
WBRT +VRS
20 (47.5 to
metastases, 38 to 2
mm PTV)
60 (223)
47.5 Gy in 5 fract.. Volumetric RS was
effective for long term control
Ferro
2017
WBRT + SIB (IMRT)
30 (35-50)
30 (1-5)
50 Gy in 10 fract. To 1-5 brain
metastases synchron. With 30 Gy
WBRT is feasible with IMRT