1200 / 1578
•
Limited data
•
In patients up to 10 mets. , the expected distant brain failure rate is not
greater than would be expected for patients with limited brain mets.
Authors
PTS
Range of
mets./Total
volume/ pts
Inclusion criteria Media
n
follow
up
Local
recurrence
DBF/Time to
DBF
OS
(median)
Yamamoto
N=208
5-10 (6)
Mean= 3.54
cc
>3 mets
Cum.Tuvol ≤ 15cc
KPS ≥70%
100% no prior
WBRT
12 mo 1 y =6.5%
2 y =9.8%
1 y = 63%
2 y =72%
Median 8.04
mo
10.8 mo
Mohammadi
N=178
5-20 (6)
median 3.2cc
KPS ≥70%
(46% no prior
WBRT)
6.2 mo Crude : 3% Crude
40%/=2.1 mo
6.7 mo
Bhatnagar
N=205
4-18 (5)
NR=CC
3 brain mets
83% prior or
adjuvant brain
mets
Mean
8.0 mo
1 y=29% 1 y =43%
Median 9 mo
8.0 mo
Multi metastases (6-17median ; range 5-35)