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Summary.
24
cases of a certain condition of chronic, intermittent, very slight
jaundice in young individuals have been observed and followed up.
In some cases this condition appeared in brothers and sisters of the
same family. In all the cases jaundice was very slight, presenting
itself only as a slight yellowish tinge in the sclerotics or in the skin.
The icterus index varied from
7
to
25
. The urine was pale, only now
and again containing urobilin. The colour of the stools was normal.
There was not any itching of the skin. The jaundice persisted for
decades, the intensity varying and being accentuated by intercurrent
diseases, such as gastro-intestinal trouble, slight colds, overwork,
lack of sleep, etc. The only subjective symptoms of the more icteric
periods was fatigue.
It is not justifiable to look upon the condition as a larvate chronic
familial acholuric jaundice, as the spleen is not enlarged, the fra
gility of the red blood cells not increased, nor has microcytosis nor
increase in reticulocyte count been demonstrated.
Neither is it justifiable to look upon it as chronic hepatitis, as
acute hepatitis was not a precursor in any case, nor were exacerba
tions observed. The character of the condition is perfectly benign.
Probably it is the same condition as was originally described by
Gilbert under the name »Cholémie simple familiale« or »Cholémie
physiologique«, and which has since been observed by different other
authors and has been described under various other names. The
present author suggests the name »Icterus intermittens juvenilis« as
most appropriate.
Litteratur.
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Eppinger, H .:
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