1384 / 1674
Endpoint: Second Lung Cancer
by time since BC diagnosis
0.5
2
1
4
Relative Risk (95% CI) IV Random
RR ES (95 CI%); Weight %
Latency period
1.39 (1.28-1.51) 100
1.59 (1.39-1.81) 100
1.66 (1.36-2.01) 100
TOTAL; I
2
= 0%
Latency ≥ 5 years
Latency ≥ 10 years
RT decreased risk
RT
increased
risk
1.49 (1.19-1.87)
12
1.36 (1.07-1.72)
11
1.38 (1.26-1.51)
77
Roychounduri 2004
Grantzau 2012
Berrington d Gonzalez, 2010
TOTAL; I
2
= 0%
1.67 (1.28-2.18)
53
1.49 (1.04-2.13)
30
1.94 (1.21-3.12)
17
Roychounduri 2004
Grantzau 2012
Zablotska 2005
,
Mastectomy
Latency ≥ 15 years
Roychounduri 2004
1.62 (1.36-1.93)
56
1.07 (0.48-2.39)
3
1.54 (1.17-2.03)
23
1.63 (1.20-2.21)
19
Grantzau 2012
Zablotska 2005,
BCS
Zablotska 2005
,
Mastectomy
TOTAL; I
2
= 0%