1383 / 1674
Endpoint: Second Lung Cancer Overall RR
Overall number of studies:
Total number of Patients:
Second Lung cancers:
Treatment years:
Range of FU:
7
631,021
4,016
1961 to 2007
0.2 to 26 years
Relative Risk (95% CI) IV Random
RR ES (95 CI%); Weight %
Studies, number of pt.
1.23 (1.07-1.43) 100
TOTAL; I
2
= 44%
0.5
1
2
4
RT
40%
NON-RT
60%
RT decreased risk
RT
increased
risk
1.07 (0.85-1.34)
18
1.33 (1.08-1.64)
20
2.31 (1.16-4.62)
4
1.28 (1.03-1.59)
19
1.10 (0.31-3.86)
1
0.94 (0.72-1.22)
16
1.27 (1.04-1.55)
20
Zablotska 2005,
Mastectomy
(194,981)
Andersson 1991
3.09 (1.12-8.53)
2
Zablotska 2005
, BCS
Roychounduri 2004
Schaapveld 2008,
<50 y
Schaapveld 2008,
>50 y
Grantzau 2012
Kirova 2007
(46,176)
(43,390)
(14,678)
(61,442)
(65,560)
(16,705)
(2,692)