Diapositive 1

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Endpoint: Second Esophagus Cancer Overall RR

1

2

Relative Risk (95% CI) IV Random

RR ES (95 CI%); Weight %

Studies, number of pt.

Overall number of studies:

Total number of Patients:

Second Esophagus cancers:

Treatment years:

Range of FU:

4

413,650

386

1961 to 2007

0.6 to 26 years

0.5

4

RT

39%

NON-RT

61%

RT decreased risk

RT

increased

risk

Roychounduri 2004

Zablotska 2005,

Mastectomy

Zablotska 2005,

BCS

Grantzau 2012

TOTAL; I

2

= 11%

1.23 (0.75-2.01)

25

Schaapveld 2008,

>50 y

Schaapveld 2008,

<50 y

(61,782)

(43,390)

(46,176)

(61,442)

(183,182)

0.93 (0.46-1.87)

14

1.86 (1.11-3.11)

24

0.64 (0.16-2.48)

4

0.85 (0.49-1.48)

21

1.17 (0.89-1.54) 100

1.17 (0.56-2.44)

13

(14,678)