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Second Cancer by Time since Treatment

RT 23,627

Non-RT 22,549

OBS

Solid Second Cancers

HR (95% CI)

RT-associated sites

Non RT-associated sites

All sites

183,490

20,661

57,926

71,902

33,001

All

≥ 15

5-9

1-4

10-14

All

≥ 15

5-9

1-4

10-14

All

≥ 15

5-9

1-4

10-14

328

56

94

100

78

226

39

66

69

52

130,765

7,273

39,034

68,678

15,780

1,102

106

353

361

228

702

45

237

318

102

1,430

216

447

461

306

928

84

303

397

154

1.00 (0.86-1.16)

1.13 (0.97-1.32)

1.16 (0.95-1.42)

1.04 (0.79-1.37)

1.10 (1.01-1.21)

1.05 (0.89-1.25)

1.11 (0.93-1.32)

1.02 (0.81-1.31)

0.76 (0.53-1.09)

1.04 (0.94-1.16)

0.81 (0.58-1.14)

1.20 (0.86-1.69)

1.55 (1.08-2.24)

1.79 (1.14-2.81)

1.34 (1.11-1.61)

years latency

years latency

years latency

years latency

years latency

years latency

years latency

years latency

years latency

years latency

years latency

years latency

OBS Person years

Person years

0 .5 1 2

3 4

Grantzau et al. Radiotherapy and Oncology 2013; 106: 42-49