Diapositive 1

Dose Response relation of Second Lung

cancer after Radiotherapy for Breast Cancer; Treatment lag ≥ 5 years



Nested case-control study on

irradiated breast cancer patients

(151 cases and 443 matched controls)



The Rate of Second Lung cancer

xxx

increased linearly with

8.5% per Gray

xxx

(95% CI = 3.1% to 23.3%; p<0.001)

xxx

Indicating that any dose reduction

xxx

would result in a decreased risk



No better fit using a linear quadratic

model (p = 0.36)

Radiation dose in Gy

Fit: Dose used as a continuous variable

Grantzau et al. Radiotherapy and Oncology

2014; June

Epub ahead of print