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Endpoint: Second Thyroid Cancer Overall RR

Overall number of studies:

Total number of Patients:

Second Thyroid cancers:

Treatment years:

Range of FU:

4

322,461

188

1961 to 2007

0.2 to 26 years

Relative Risk (95% CI) IV Random

RR ES (95 CI%); Weight %

Studies, number of pt.

RT

37%

NON-RT

63%

1.00 (0.66-1.51)

56

1.32 (0.49-3.57)

9

1.33 (0.39-4.53)

6

1.03 (0.58-1.82)

29

1.05 (0.78-1.43) 100

Huang 2001

Grantzau 2012

(61,442)

(46,176)

0.5

1

2

4

Roychounduri 2004

Kirova 2007

(16,705)

(194,798)

TOTAL; I

2

= 0%

RT decreased risk

RT

increased

risk