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Meta-analysis on second cancers after Radiotherapy for Breast
Cancer: 762,468 Breast Cancer Patients
Inclusion:
Cohort studies that compared irradiated early breast cancer patients with un-
irradiated patients.
Outcome:
Studies had to report risk estimates of second cancer; either as the RR or HR
together with the corresponding 95% CI.
Meta-analysis based on random effects models; to allow for between study variation.
Data Source:
•
9 population based cohort studies
•
3 single institution cohort studies
•
1 regional prospective study
Region:
The study population comprised European or North American populations of
female breast cancer patients
Study population 13 included studies
•
Cumulative size: 1,661,193 women
•
Eliminating overlapping cohorts: 762,468
•
RT treated: 321,325 (42%)
•
Non RT treated: 441,325 (58%)
Grantzau & Overgaard, R&O 2016