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Effect of random dosimetric uncertainty (SD) on mean

simulated dose response data for OAR D

2cm³ 

Simulated patient data

Calculated dose-response curve for

(S SS)

simulated patients P

SD 10% per BT fraction

SD 20%

SD 30%

Increasing offset with increasing dose and increasing random dosimetric uncertainty:

2-3 % for SD 20% and 30% around rectum dose constraint level

Nesvacil et al. 2016, R&O, submitted