1101 / 1228
Example: random uncertainties for target OAR
Random variation of target D
90,
e.g. random inter-observer variation
Random variation of rectum D
2cm³
e.g. random intra-/inter-fraction variation of
organ position or shape
•
D
2 ³
=
±
10%/fx -> observed morbidity 7.5 %
For target – differences in TCP < 0.5%
cm
(vs 7.3% model prediction)
•
D
2cm³
=
±
20%/fx -> observed morbidity 8.9 %
•
D
2cm³
=
±
30%/fx -> observed morbidity 10.5 %
•
Model prediction: 10.5% NTCP@ 80Gy EQD2
“Can reduction of uncertainties in cervix cancer brachytherapy potentially
improve clinical outcome?” Nesvacil et al. 2016, submitted to R&O