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Example: influence of the number of BT Fx
Random uncertainties and dose response for different fractionation schemes
Example: random uncertainty
D
2cm³
=
±
20%/fx:
•
nFx=5 => observed morbidity @75Gy 8 5%
For target: using 1 Fx vs 2-5Fx results in
~0 5% lower tumour control probability than
.
•
nFx=4 => observed morbidity @75Gy 8.9%
•
nFx=3 => observed morbidity @75Gy 9.4%
•
nFx=2 => observed morbidity @75Gy 10.3%
.
predicted by model
•
nFx=1 => observed morbidity @75Gy 12.3%
“Can reduction of uncertainties in cervix cancer brachytherapy potentially
improve clinical outcome?” Nesvacil et al. 2016, submitted to R&O