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2. Is there information
demonstrating that the
method system suitability
tests and controls as
specified in the SMPR worked
appropriately and as
expected? If no, please
specify.
3. Based on the supporting
information, is the method
written clearly and concisely?
If no, please specify the
needed revisions.
4. Based on the supporting
information, what are the
pros/strengths of the
method?
5. Based on the supporting
information, what are the
cons/weaknesses of the
method?
6. Any general comments
about the method?
Do you recommend this method be
adopted as a First Action and
published in the Official Methods
of Analysis of AOAC
INTERNATIONAL?
Please specify rationale.
Yes
Yes
Comprehensive evaluation of the specified marker peptides in selected matrices in
selected samples. The concept evaluated is a strong point of the method.
The method has been demonstrated to be applicable to selected matrices. The
contents of unique marker peptide is different in even in the same matrix type like
cookie thus method may requires separate calibration curve for every sample type even
for those matrices where it has been demonstrated to be working. The method has not
been demonstrated for its performance in different types of the matrices in scope like
Cookie etc.
It's a very good concept but how practical to apply it in field not known. The methods
accuracy not established using other reference materials (which have not used to
calibrate the method) and by analysis using other established methods for the same
samples.
The method may be adopted as a First Action for only matrices for which its
performance has been demonstrated satisfactory in the submitted report.
V. Final Recommendation