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2. Is there information

demonstrating that the

method system suitability

tests and controls as

specified in the SMPR worked

appropriately and as

expected? If no, please

specify.

3. Based on the supporting

information, is the method

written clearly and concisely?

If no, please specify the

needed revisions.

4. Based on the supporting

information, what are the

pros/strengths of the

method?

5. Based on the supporting

information, what are the

cons/weaknesses of the

method?

6. Any general comments

about the method?

Do you recommend this method be

adopted as a First Action and

published in the Official Methods

of Analysis of AOAC

INTERNATIONAL?

Please specify rationale.

Yes

Yes

Comprehensive evaluation of the specified marker peptides in selected matrices in

selected samples. The concept evaluated is a strong point of the method.

The method has been demonstrated to be applicable to selected matrices. The

contents of unique marker peptide is different in even in the same matrix type like

cookie thus method may requires separate calibration curve for every sample type even

for those matrices where it has been demonstrated to be working. The method has not

been demonstrated for its performance in different types of the matrices in scope like

Cookie etc.

It's a very good concept but how practical to apply it in field not known. The methods

accuracy not established using other reference materials (which have not used to

calibrate the method) and by analysis using other established methods for the same

samples.

The method may be adopted as a First Action for only matrices for which its

performance has been demonstrated satisfactory in the submitted report.

V. Final Recommendation