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113

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

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Ion transporters and pumps play an important role within general

metabolism and information processing of organisms. The SURFE2R

is a unique platform for direct measurements ion transporters and ion

channels in diverse and heterologous membranes. It is easy-to-handle,

highly sensitive and a very efficient screening platform. The SURFE2R

N1 is a small footprint, fully automated device recording from membrane

preparations, with proven success using native tissue, mammalian and

insect cell lines, bacteria, organelles, and proteoliposomes.

Join this workshop for hands-on experiments and information about three

outstanding platforms: Port-a-Patch, Orbit 16 and SURFE2R N1! We

look forward to seeing you!

Spaces are limited so reserve yours by sending an email to

info@nanion.de

.

Presenters

Andrea Brüggemann, CSO, Nanion Technologies GmbH

Maria Barthmes, Application Specialist, Nanion Technologies GmbH

Gerhard Baaken, CEO, Ionera

1:00

pm

–3:00

pm

, H

all

C

Industry and Agency Opportunities Fair

This fair will introduce attendees to companies and agencies that have

employment and funding opportunities outside of academia. Stop by

the fair to learn about the variety of opportunities available to scientists

in industry and government and to talk one-on-one with representatives

from participating organizations. Don’t forget to check out the Career

Center, Room 301/302/303, for current job prospects offered by many of

the participating organizations.

1:30

pm

–3:00

pm

, H

all

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Exhibitor Presentation

KinTek Corporation

KinTek Explorer Software: New Advances in Fitting Kinetic and

Equilibrium Data

Fitting kinetic data based upon numerical integration of rate equations

offers many advantages over conventional fitting of data based upon

equations derived from simple models. Fitting by simulation is the most

rigorous and eliminates numerous errors in simplifying assumptions

needed to derive equations. Every day papers are published that contain

errors in kinetic analysis that could have been avoided if the data had been

fit using KinTek Explorer software.

In this presentation, Dr. Johnson will show how global fitting of kinetic

data can be accomplished with ease using the fast, dynamic simulation

in KinTek Explorer software, overcoming the all-to-common errors in

conventional fitting. Moreover, data are fit to derive rate constants directly

defining steps in a model, not merely observed rates (Eigenvalues). New

advances in the software allow fitting kinetic data from single molecule

experiments and families of curves can be fit simultaneous to define

voltage-dependent rate constants or data from Temperature-jump or

Pressure-jump experiments. In addition, equilibrium titration data can be

fit using a unique endpoint simulation method, and time-resolved spectra

can be fit using singular value decomposition (SVD). All experiments can

be fit simultaneously and accurate error estimates are derived using robust

confidence contour analysis.

Presenters

Kenneth A. Johnson, President, KinTek Corporation

Roger Williams, Professor of Biochemistry, University of Texas at Austin

1:30

pm

–2:30

pm

, R

oom

309/310

Conversation with NIGMS Director

Jon Lorsch

Jon Lorsch assumed the role of Director of the National Institute of

General Medical Sciences in 2013. One year in, he is leading a five-year

strategic planning effort at NIH for the Institute and examining how

the Institute can make the most of its resources to support fundamental

research. Come to this session to learn more about Lorsch’s vision for

NIGMS as well as what is new at the Institute.

1:45

pm

–3:00

pm

, H

all

C

Snack Break

2:30

pm

–3:30

pm

, R

oom

301/302/303

Career Center Workshop

Ten Tough Industrial Interview Questions

(and Ten Pretty Good Responses)

You’ve been invited to interview with that drug development company

that you’ve always wanted to work for. You’ve soaked up the details of the

position description. You are confident in your ability to do the job, as

well as answer any/all technical questions during the interview process.

The day is yours…until…that first question catches you by surprise

and your confidence begins to wilt. Be prepared for those non-technical

questions that you will almost certainly hear at some point, know why

they are asked, and learn what a good (if not great) response to each

question might be by attending this workshop.

2:30

pm

–4:30

pm

, R

oom

330

Grant Opportunities for Early Career Faculty

In this panel, hosted by the Early Careers Committee, program

coordinators and research administrators from key funding agencies will

discuss and answer questions about the timeline, strategies, and funding

opportunities for new faculty working to establish their independent

laboratories.

Speakers

Bishow Adhikari, NIH

Beth Schachter, Beth Schachter Consulting

Kamal Shukla, NSF

3:00

pm

–4:00

pm

, R

oom

327/328/329

Networking with Minority Biophysicists:

Resources and Opportunities

This networking event, sponsored by the Minority Affairs Committee,

provides minority students and scientists the opportunity to network and

discuss challenges and resources with other minority biophysicists.

3:00

pm

–5:00

pm

, R

oom

333

Education Committee Meeting

4:00

pm

–6:00

pm

, B

allroom

I

Symposium

Nanoclustering of Membranes and

Membrane Proteins

Chair

Ka Yee Lee, University of Chicago

1796-S

ymp

4:00

pm

STRUCTURE AND FUNCTION OF MEMBRANE-REMODELING

ESCRT-III ASSEMBLIES. John McCullough, Marissa Saunders, Leremy

Colf, Wes Sundquist,

Adam Frost