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109
Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
T
U
E
S
D
A
Y
9:00
am
–10:00
am
, R
oom
318
Subgroup Chairs Meeting
9:30
am
–10:30
am
, R
oom
301/302/303
Career Center Workshop
Successfully Navigating the International
Job Search
Applying for a job in one country while finishing up your education and
training in another can be challenging, but it can be done with success. In
this workshop we will discuss specific strategies to finding jobs in another
country while one is abroad and how to leverage your networks in-country
to access opportunities, especially those that are hidden. Special emphasis
will be placed on establishing your reputation as a leader in your field with
professionals in the country or region in which you wish to work. Case
studies will be shared.
10:00
am
–5:00
pm
, H
all
C
Biomolecular Discovery Dome
Visit this 3-D portable Dome, sponsored by the Public Affairs Committee,
to see how difficult biophysical topics can be made accessible to high
school students and the public. Short videos that communicate the
excitement of looking at macromolecular complexes and understanding
the molecular basis for life are being shown throughout the week.
10:00
am
–5:00
pm
, H
all
C
Exhibits
10:15
am
–11:00
am
, H
all
C
Coffee Break
10:30
am
–12:00
pm
, H
all
C, R
oom
B
Exhibitor Presentation
SensiQ Technologies Inc
High End Microscope Platform for Multimodal Live Cell Imaging
SensiQ’s dynamic injection methods provide complete, one-pass kinetic
and equilibrium data from a single injection while reducing statistical
error/noise. Simply load one, highest analyte concentration vial and
the instrument exposes the surface to either a stepwise (FastStep®) or
continuous gradient (OneStep®) of concentrations. These approaches
increase the ease/throughput of SPR experiments and provide complete
data sets for interactions that are complicated by incomplete surface
regeneration. FastStep® uses a patented onboard micro-mixing technique
to create increasing fixed concentrations of analyte in real time without
generating partial dissociation responses as the instrument prepares
subsequent concentrations. This technique improves throughput by
decreasing the time to complete a full run while simplifying data analysis.
OneStep® is the ultimate evolution of FastStep®. Taylor dispersion
fluidics establish a continuous gradient of analyte concentrations which
is flowed over the surface to generate a sigmoidal binding curve. This
technique introduces a time dependent variable that is not possible in
traditional injection techniques and allows for the quantitative separation
of multiple binding sites with different affinities. OneStep® also increases
the dynamic range of allowable concentrations thereby removing the need
to perform test injections or accurately guess the affinity of an unknown
interaction. Importantly, OneStep® also provides added data content
in SPR experiments by providing a measure of the analyte diffusion
coefficient to help identify analytes that have a tendency to oligomerize or
aggregate. SensiQs’ operational software was developed to simplify assay
development and instrument operation. Using a drag and drop icon based
programming approach, traditional program “scripting” is eliminated
to simplify and speed assay development. Executable protocols for high
throughput experiments can be developed in minutes. Programming
examples will show how operational actions have been optimized to
decrease runtime and increase throughput. Streamlining data analysis of
small or large data sets using our Q-Dat software will also be presented.
Presenters
Derek Beahm, SensiQ Application Scientist
Rick Cope, SensiQ Sales Representative
10:45
am
–12:45
pm
, B
allroom
I
Symposium
Awards Symposium
Chair
Dorothy Beckett, University of Maryland, Society President
N
o
A
bstract
10:45
am
RECENT PROGRESS ON OLD PROBLEMS.
Harold Scheraga
N
o
A
bstract
11:05
am
MEMBRANE PROTEINS NEED LIPIDS.
Anthony Watts
N
o
A
bstract
11:25
am
EVOLUTION AND ASSEMBLY OF PROTEIN COMPLEXES.
Sarah Teichmann
N
o
A
bstract
11:45
am
SURPRISES I FOUND IN STUDYING MEMBRANES.
Gerald W. Feigenson
N
o
A
bstract
12:05
pm
TALES OF TUBULIN TAILS.
Antonina Roll-Mecak
N
o
A
bstract
1:25
pm
FROM CYTOKINESIS TO THE EARLY MOUSE EMBRYO
DEVELOPMENT: A SIMPLE PHYSICAL VIEW OF CELL
MORPHOGENESIS.
Hervé Turlier
10:45
am
–12:45
pm
, B
allroom
II
Platform
Protein Fold Stability
Co-Chairs
Dominika Gruszka, Cambridge University, United Kingdom
Nathaniel Nucci, Rowan University
1740-P
lat
10:45
am
THE FOLDING OF SASG: A LONG AND REMARKABLY
STRONG MONOMERIC PROTEIN RESPONSIBLE FOR BIOFILM
FORMATION IS A HIGHLY COOPERATIVE SYSTEM.
Dominika T. Gruszka
, Fiona Whelan, Emanuele Paci, David J.
Brockwell, Jennifer R. Potts, Jane Clarke
1741-P
lat
11:00
am
PUTTING ON THE SQUEEZE: SOLUTION NMR
INVESTIGATIONS OF PROTEIN STRUCTURE AND
HYDRATION UNDER HIGH PRESSURE.
Nathaniel V. Nucci
, Brian
Fuglestad, Connie Liao, Evangelia A. Athanasoula, A. Joshua Wand
1742-P
lat
11:15
am
EFFECTS OF CROWDING, OSMOLYTES, TEMPERATURE AND
PRESSURE ON THE INTERACTION POTENTIAL OF DENSE
PROTEIN SOLUTIONS.
Roland Winter
1743-P
lat
11:30
am
A MULTISCALE MODEL FOR PH-DEPENDENT FOLDING AND
BINDING OF A CONDITIONALLY DISORDERED CHAPERONE.
Logan S. Ahlstrom
, Sean M. Law, Alex Dickson, Charles L. Brooks III